@article {1195, title = {Prevalence of asymptomatic carotid artery stenosis in the general population: an individual participant data meta-analysis.}, journal = {Stroke}, volume = {41}, year = {2010}, month = {2010 Jun}, pages = {1294-7}, abstract = {

BACKGROUND AND PURPOSE: In the discussion on the cost-effectiveness of screening, precise estimates of severe asymptomatic carotid stenosis are vital. Accordingly, we assessed the prevalence of moderate and severe asymptomatic carotid stenosis by age and sex using pooled cohort data.

METHODS: We performed an individual participant data meta-analysis (23 706 participants) of 4 population-based studies (Malm{\"o} Diet and Cancer Study, Troms{\o}, Carotid Atherosclerosis Progression Study, and Cardiovascular Health Study). Outcomes of interest were asymptomatic moderate (> or =50\%) and severe carotid stenosis (> or =70\%).

RESULTS: Prevalence of moderate asymptomatic carotid stenosis ranged from 0.2\% (95\% CI, 0.0\% to 0.4\%) in men aged <50 years to 7.5\% (5.2\% to 10.5\%) in men aged > or =80 years. For women, this prevalence increased from 0\% (0\% to 0.2\%) to 5.0\% (3.1\% to 7.5\%). Prevalence of severe asymptomatic carotid stenosis ranged from 0.1\% (0.0\% to 0.3\%) in men aged <50 years to 3.1\% (1.7\% to 5.3\%) in men aged > or =80. For women, this prevalence increased from 0\% (0.0\% to 0.2\%) to 0.9\% (0.3\% to 2.4\%).

CONCLUSIONS: The prevalence of severe asymptomatic carotid stenosis in the general population ranges from 0\% to 3.1\%, which is useful information in the discussion on the cost-effectiveness of screening.

}, keywords = {Adult, Age Factors, Aged, Aged, 80 and over, Carotid Stenosis, Female, Humans, Male, Mass Screening, Middle Aged, Prevalence, Severity of Illness Index, Sex Factors}, issn = {1524-4628}, doi = {10.1161/STROKEAHA.110.581058}, author = {de Weerd, Marjolein and Greving, Jacoba P and Hedblad, Bo and Lorenz, Matthias W and Mathiesen, Ellisiv B and O{\textquoteright}Leary, Daniel H and Rosvall, Maria and Sitzer, Matthias and Buskens, Erik and Bots, Michiel L} }