@article {1412, title = {High density lipoprotein cholesterol is associated with serum cortisol in older people.}, journal = {J Am Geriatr Soc}, volume = {43}, year = {1995}, month = {1995 Dec}, pages = {1345-9}, abstract = {

OBJECTIVE: To determine the associations between serum cortisol and HDL cholesterol, other lipoprotein lipids and cardiovascular risk factors, carotid atherosclerosis, and clinical heart disease in older people.

DESIGN: A cross-sectional, observational, ancillary study of the Cardiovascular Health Study (CHS).

POPULATION: A total of 245 community-dwelling people, 65 to 89 years old, were recruited consecutively for a 2-month period from the CHS cohort in Forsyth County, North Carolina.

METHODS: Cortisol was measured by radioimmunoassay in serum collected between 7:00 and 10:00 AM after an overnight fast. Cortisol levels were correlated with lipoprotein lipids, insulin, glucose, body mass index, waist-hip ratio, prevalent coronary heart disease, hypertension, diabetes, and carotid atherosclerosis by B-mode ultrasound.

RESULTS: Serum cortisol was correlated negatively (r = -.24) with body mass index and waist-hip ratio (r = -.16) but was not related significantly to fasting insulin or glucose. Cortisol was not associated significantly with triglyceride and low density lipoprotein cholesterol but showed a positive correlation (r = .21) with high density lipoprotein cholesterol. The relationship between cortisol and high density lipoprotein cholesterol persisted after adjustment for gender, body mass index, waist-hip ratio, cigarette and alcohol use, triglyceride level, and diabetes. There was a trend toward a negative correlation between cortisol and measures of carotid atherosclerosis, but no significant relationship was indicated between cortisol and prevalent coronary heart disease, hypertension, or diabetes.

CONCLUSION: Endogenous glucocorticoid levels correlated with HDL cholesterol levels and may play a role in the physiologic regulation of high density lipoprotein levels in older people.

}, keywords = {Aged, Body Constitution, Body Mass Index, Cardiovascular Diseases, Carotid Stenosis, Cholesterol, HDL, Coronary Disease, Cross-Sectional Studies, Diabetes Mellitus, Female, Humans, Hydrocortisone, Hypertension, Male, Prevalence, Risk Factors}, issn = {0002-8614}, author = {Varma, V K and Rushing, J T and Ettinger, W H} }