@article {7118, title = {Lack of association of plasma gamma prime (γ{\textquoteright}) fibrinogen with incident cardiovascular disease.}, journal = {Thromb Res}, volume = {143}, year = {2016}, month = {2016 Jul}, pages = {50-2}, abstract = {

INTRODUCTION: The association of gamma prime (γ{\textquoteright}) fibrinogen; a fibrinogen γ chain variant generated via alternative mRNA processing, with cardiovascular disease (CVD) remains equivocal. We prospectively examine the association of plasma γ{\textquoteright} fibrinogen with the incidence of multiple cardiovascular disease (CVD) endpoints, independent of established CVD risk factors and total fibrinogen.

MATERIALS AND METHODS: We measured plasma γ{\textquoteright} fibrinogen on plasma samples collected in 1992-1993 from adults >=65years (n=3219) enrolled in the Cardiovascular Health Study, who were followed through 2013 for incident CVD events.

RESULTS AND CONCLUSIONS: In multivariable Cox models adjusted for traditional CVD risk factors and total fibrinogen, the hazard ratio per 1 standard deviation (10.7mg/dl) increment of γ{\textquoteright} fibrinogen was 1.02 (95\%CI: 0.95-1.10) for coronary heart disease; 0.88 (0.77-1.00) for ischemic stroke; 1.07 (0.87-1.32) for peripheral artery disease; 1.00 (0.92-1.08) for heart failure and 1.01 (0.92-1.10) for CVD mortality. Likewise, we failed to show a statistically significant association of γ{\textquoteright}/total fibrinogen ratio with any CVD endpoint. These results suggest that among the elderly, γ{\textquoteright} fibrinogen does not add much to CVD prediction beyond traditional risk factors and total fibrinogen level.

}, issn = {1879-2472}, doi = {10.1016/j.thromres.2016.04.023}, author = {Appiah, Duke and Heckbert, Susan R and Cushman, Mary and Psaty, Bruce M and Folsom, Aaron R} }