@article {7545, title = {Role of Late-Life Depression in the Association of Subclinical Cardiovascular Disease With All-Cause Mortality: Cardiovascular Health Study.}, journal = {J Aging Health}, year = {2017}, month = {2017 Nov 01}, pages = {898264317744921}, abstract = {

OBJECTIVES: To evaluate whether late-life depression mediates the association of subclinical cardiovascular disease (CVD) with all-cause mortality.

METHOD: Using data from 3,473 Cardiovascular Health Study participants, the Cox proportional hazards model was used to examine the direct and indirect (via late-life depression) effects of the association between baseline subclinical CVD and all-cause mortality with weights derived from multivariable logistic regression of late-life depression on subclinical CVD.

RESULTS: Subclinical CVD led to a higher risk of all-cause mortality (hazard ratio [HR] = 1.51, 95\% confidence interval, [CI] = [1.42, 1.94]). Total effect of subclinical CVD on all-cause mortality was decomposed into direct (HR = 1.41, 95\% CI = [1.37, 1.58]) and indirect (HR = 1.07, 95\% CI = [1.01, 1.23]) effects; 16.3\% of the total effect of subclinical CVD on all-cause mortality was mediated by late-life depression.

DISCUSSION: Late-life depression accounts for little, if any, of the association between subclinical CVD, a risk factor of all-cause mortality, and all-cause mortality.

}, issn = {1552-6887}, doi = {10.1177/0898264317744921}, author = {Armstrong, Nicole M and Carlson, Michelle C and Xue, Qian-Li and Schrack, Jennifer and Carnethon, Mercedes R and Chaves, Paulo H M and Gross, Alden L} }