@article {7987, title = {Genetically elevated high-density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer{\textquoteright}s disease.}, journal = {Alzheimers Dement (Amst)}, volume = {10}, year = {2018}, month = {2018}, pages = {595-598}, abstract = {

Introduction: There is conflicting evidence whether high-density lipoprotein cholesterol (HDL-C) is a risk factor for Alzheimer{\textquoteright}s disease (AD) and dementia. Genetic variation in the cholesteryl ester transfer protein () locus is associated with altered HDL-C. We aimed to assess AD risk by genetically predicted HDL-C.

Methods: Ten single nucleotide polymorphisms within the locus predicting HDL-C were applied to the International Genomics of Alzheimer{\textquoteright}s Project (IGAP) exome chip stage 1 results in up 16,097 late onset AD cases and 18,077 cognitively normal elderly controls. We performed instrumental variables analysis using inverse variance weighting, weighted median, and MR-Egger.

Results: Based on 10 single nucleotide polymorphisms distinctly predicting HDL-C in the locus, we found that HDL-C was not associated with risk of AD (~>~.7).

Discussion: Our study does not support the role of HDL-C on risk of AD through HDL-C altered by . This study does not rule out other mechanisms by which HDL-C affects risk of AD.

}, issn = {2352-8729}, doi = {10.1016/j.dadm.2018.08.008}, author = {Peloso, Gina M and van der Lee, Sven J and DeStefano, Anita L and Seshardi, Sudha} }