@article {8793, title = {Body mass index in early adulthood and dementia in late life: Findings from a pooled cohort.}, journal = {Alzheimers Dement}, year = {2021}, month = {2021 May 13}, abstract = {

INTRODUCTION: To examine the independent association of body mass index (BMI) in early adulthood with dementia incidence among men and women.

METHODS: We studied 5104 older adults from the Cardiovascular Health Study (CHS) and the Health, Aging, and Body Composition (Health ABC) study. We imputed early adulthood and midlife BMI using a pooled parent cohort with complete adult lifespan coverage and previously established methods. Dementia was ascertained using criteria such as neuropsychological test battery, medical records, and dementia-related drug use. Pooled logistic regression (PLR) models were used.

RESULTS: Compared to women with normal BMI in early adulthood, the odds of dementia were higher among both overweight (odds ratio [OR]~=~1.8; 95\% confidence interval [CI]~=~1.31 to 2.54) and obese (OR~=~2.45; 95\% CI~=~1.47 to 4.06) women, independent of mid- and late-life BMI. Similar relationship was observed in men.

CONCLUSIONS: With the growing obesity epidemic among US adults, efforts aimed at reducing dementia may need to begin obesity prevention and treatment early in the life course.

}, issn = {1552-5279}, doi = {10.1002/alz.12367}, author = {Zeki Al Hazzouri, Adina and Vittinghoff, Eric and Hoang, Tina and Golden, Sherita H and Fitzpatrick, Annette L and Zhang, Adina and Grasset, Leslie and Yaffe, Kristine} }