@article {9700,
	title = {A plasma protein-based risk score to predict hip fractures.},
	journal = {Nat Aging},
	year = {2024},
	month = {2024 May 27},
	abstract = {<p>As there are effective treatments to reduce hip fractures, identification of patients at high risk of hip fracture is important to inform efficient intervention strategies. To obtain a new tool for hip fracture prediction, we developed a protein-based risk score in the Cardiovascular Health Study using an aptamer-based proteomic platform. The proteomic risk score predicted incident hip fractures and improved hip fracture discrimination in two Tr{\o}ndelag Health Study validation cohorts using the same aptamer-based platform. When transferred to an antibody-based proteomic platform in a UK Biobank validation cohort, the proteomic risk score was strongly associated with hip fractures (hazard ratio per s.d. increase, 1.64; 95\% confidence interval 1.53-1.77). The proteomic risk score, but not available polygenic risk scores for fractures or bone mineral density, improved the C-index beyond the fracture risk assessment tool (FRAX), which integrates information from clinical risk factors (C-index, FRAX 0.735 versus FRAX + proteomic risk score 0.776). The developed proteomic risk score constitutes a new tool for stratifying patients according to hip fracture risk; however, its improvement in hip fracture discrimination is modest and its clinical utility beyond FRAX with information on femoral neck bone mineral density remains to be determined.</p>},
	issn = {2662-8465},
	doi = {10.1038/s43587-024-00639-7},
	author = {Austin, Thomas R and Nethander, Maria and Fink, Howard A and T{\"o}rnqvist, Anna E and Jalal, Diana I and B{\r u}zkov{\'a}, Petra and Barzilay, Joshua I and Carbone, Laura and Gabrielsen, Maiken E and Grahnemo, Louise and Lu, Tianyuan and Hveem, Kristian and Jonasson, Christian and Kizer, Jorge R and Langhammer, Arnulf and Mukamal, Kenneth J and Gerszten, Robert E and Psaty, Bruce M and Robbins, John A and Sun, Yan V and Skogholt, Anne Heidi and Kanis, John A and Johansson, Helena and {\r A}svold, Bj{\o}rn Olav and Valderr{\'a}bano, Rodrigo J and Zheng, Jie and Richards, J Brent and Coward, Eivind and Ohlsson, Claes}
}
