@article {9861,
	title = {Gene-Excessive Sleepiness Interactions Suggest Treatment Targets for Obstructive Sleep Apnea Subtype.},
	journal = {medRxiv},
	year = {2024},
	month = {2024 Oct 28},
	abstract = {<p>Obstructive sleep apnea (OSA) is a multifactorial sleep disorder characterized by a strong genetic basis. Excessive daytime sleepiness (EDS) is a symptom that is reported by a subset of OSA patients, persisting even after treatment with continuous positive airway pressure (CPAP). It is recognized as a clinical subtype underlying OSA carrying alarming heightened cardiovascular risk. Thus, conceptualizing EDS as an exposure variable, we sought to investigate EDS{\textquoteright}s influence on genetic variation linked to apnea-hypopnea index (AHI), a diagnostic measure of OSA severity. This study serves as the first large-scale genome-wide gene x environment interaction analysis for AHI, investigating the interplay between its genetic markers and EDS across and within specific sex. Our work pools together whole genome sequencing data from seven cohorts, enabling a diverse dataset (four population backgrounds) of over 11,500 samples. Among the total 16 discovered genetic targets with interaction evidence with EDS, eight are previously unreported for OSA, including , , and  identified in all sexes; , , and  identified in males; and  and  identified in females. We discuss connections to insulin resistance, thiamine deficiency, and resveratrol use that may be worthy of therapeutic consideration for excessively sleepy OSA patients.</p>},
	doi = {10.1101/2024.10.25.24316158},
	author = {Nagarajan, Pavithra and Kurniansyah, Nuzulul and Lee, Jiwon and Gharib, Sina A and Xu, Yushan and Zhang, Yiyan and Spitzer, Brian and Faquih, Tariq and Zhou, Hufeng and Boerwinkle, Eric and Chen, Han and Gottlieb, Daniel J and Guo, Xiuqing and Heard-Costa, Nancy L and Hidalgo, Bertha A and Levy, Daniel and Liu, Peter Y and Mei, Hao and Montalvan, Rebecca and Mukherjee, Sutapa and North, Kari E and O{\textquoteright}Conner, George T and Palmer, Lyle J and Patel, Sanjay R and Psaty, Bruce M and Purcell, Shaun M and Raffield, Laura M and Rich, Stephen S and Rotter, Jerome I and Saxena, Richa and Smith, Albert V and Stone, Katie L and Zhu, Xiaofeng and Cade, Brian E and Sofer, Tamar and Redline, Susan and Wang, Heming}
}
