@article {8514,
	title = {{New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders},
	journal = {Nat Hum Behav},
	volume = {3},
	year = {2019},
	month = {09},
	pages = {950{\textendash}961},
	abstract = {Excessive alcohol consumption is one of the main causes of death and disability worldwide. Alcohol consumption is a heritable complex trait. Here we conducted a meta-analysis of genome-wide association studies of alcohol consumption (g d-1) from the UK Biobank, the Alcohol Genome-Wide Consortium and the Cohorts for Heart and Aging Research in Genomic Epidemiology Plus consortia, collecting data from 480,842 people of European descent to decipher the genetic architecture of alcohol intake. We identified 46 new common loci and investigated their potential functional importance using magnetic resonance imaging data and gene expression studies. We identify genetic pathways associated with alcohol consumption and suggest genetic mechanisms that are shared with neuropsychiatric disorders such as schizophrenia.},
	author = {Evangelou, E. and Gao, H. and Chu, C. and Ntritsos, G. and Blakeley, P. and Butts, A. R. and Pazoki, R. and Suzuki, H. and Koskeridis, F. and Yiorkas, A. M. and Karaman, I. and Elliott, J. and Luo, Q. and Aeschbacher, S. and Bartz, T. M. and Baumeister, S. E. and Braund, P. S. and Brown, M. R. and Brody, J. A. and Clarke, T. K. and Dimou, N. and Faul, J. D. and Homuth, G. and Jackson, A. U. and Kentistou, K. A. and Joshi, P. K. and Lemaitre, R. N. and Lind, P. A. and Lyytik?inen, L. P. and Mangino, M. and Milaneschi, Y. and Nelson, C. P. and Nolte, I. M. and Per?l?, M. M. and Polasek, O. and Porteous, D. and Ratliff, S. M. and Smith, J. A. and Stan??kov?, A. and Teumer, A. and Tuominen, S. and Th?riault, S. and Vangipurapu, J. and Whitfield, J. B. and Wood, A. and Yao, J. and Yu, B. and Zhao, W. and Arking, D. E. and Auvinen, J. and Liu, C. and M?nnikk?, M. and Risch, L. and Rotter, J. I. and Snieder, H. and Veijola, J. and Blakemore, A. I. and Boehnke, M. and Campbell, H. and Conen, D. and Eriksson, J. G. and Grabe, H. J. and Guo, X. and van der Harst, P. and Hartman, C. A. and Hayward, C. and Heath, A. C. and Jarvelin, M. R. and K?h?nen, M. and Kardia, S. L. R. and K?hne, M. and Kuusisto, J. and Laakso, M. and Lahti, J. and Lehtim?ki, T. and McIntosh, A. M. and Mohlke, K. L. and Morrison, A. C. and Martin, N. G. and Oldehinkel, A. J. and Penninx, B. W. J. H. and Psaty, B. M. and Raitakari, O. T. and Rudan, I. and Samani, N. J. and Scott, L. J. and Spector, T. D. and Verweij, N. and Weir, D. R. and Wilson, J. F. and Levy, D. and Tzoulaki, I. and Bell, J. D. and Matthews, P. M. and Rothenfluh, A. and Desrivi?res, S. and Schumann, G. and Elliott, P.}
}
@article {8657,
	title = {{Genome-Wide Association Study of Circulating Interleukin 6 Levels Identifies Novel Loci},
	journal = {Hum Mol Genet},
	year = {2021},
	month = {Jan},
	abstract = {Interleukin-6 (IL-6) is a multifunctional cytokine with both pro- and anti-inflammatory properties with a heritability estimate of up to 61\%. The circulating levels of IL-6 in blood have been associated with an increased risk of complex disease pathogenesis. We conducted a two-staged, discovery, and replication meta genome-wide association study (GWAS) of circulating serum IL-6 levels comprising up to 67 428 (ndiscovery = 52 654 and nreplication = 14 774) individuals of European ancestry. The inverse variance fixed-effects based discovery meta-analysis, followed by replication led to the identification of two independent loci, IL1F10/IL1RN rs6734238 on Chromosome (Chr) 2q14, (pcombined = 1.8 {\texttimes} 10-11), HLA-DRB1/DRB5 rs660895 on Chr6p21 (pcombined = 1.5 {\texttimes} 10-10) in the combined meta-analyses of all samples. We also replicated the IL6R rs4537545 locus on Chr1q21 (pcombined = 1.2 {\texttimes} 10-122). Our study identifies novel loci for circulating IL-6 levels uncovering new immunological and inflammatory pathways that may influence IL-6 pathobiology.},
	author = {Ahluwalia, T. S. and Prins, B. P. and Abdollahi, M. and Armstrong, N. J. and Aslibekyan, S. and Bain, L. and Jefferis, B. and Baumert, J. and Beekman, M. and Ben-Shlomo, Y. and Bis, J. C. and Mitchell, B. D. and de Geus, E. and Delgado, G. E. and Marek, D. and Eriksson, J. and Kajantie, E. and Kanoni, S. and Kemp, J. P. and Lu, C. and Marioni, R. E. and McLachlan, S. and Milaneschi, Y. and Nolte, I. M. and Petrelis, A. M. and Porcu, E. and Sabater-Lleal, M. and Naderi, E. and Sepp{\"a}l{\"a}, I. and Shah, T. and Singhal, G. and Standl, M. and Teumer, A. and Thalamuthu, A. and Thiering, E. and Trompet, S. and Ballantyne, C. M. and Benjamin, E. J. and Casas, J. P. and Toben, C. and Dedoussis, G. and Deelen, J. and Durda, P. and Engmann, J. and Feitosa, M. F. and Grallert, H. and Hammarstedt, A. and Harris, S. E. and Homuth, G. and Hottenga, J. J. and Jalkanen, S. and Jamshidi, Y. and Jawahar, M. C. and Jess, T. and Kivimaki, M. and Kleber, M. E. and Lahti, J. and Liu, Y. and Marques-Vidal, P. and Mellstr{\"o}m, D. and Mooijaart, S. P. and M{\"u}ller-Nurasyid, M. and Penninx, B. and Revez, J. A. and Rossing, P. and R{\"a}ikk{\"o}nen, K. and Sattar, N. and Scharnagl, H. and Sennblad, B. and Silveira, A. and Pourcain, B. S. and Timpson, N. J. and Trollor, J. and van Dongen, J. and van Heemst, D. and Visvikis-Siest, S. and Vollenweider, P. and V{\"o}lker, U. and Waldenberger, M. and Willemsen, G. and Zabaneh, D. and Morris, R. W. and Arnett, D. K. and Baune, B. T. and Boomsma, D. I. and Chang, Y. C. and Deary, I. J. and Deloukas, P. and Eriksson, J. G. and Evans, D. M. and Ferreira, M. A. and Gaunt, T. and Gudnason, V. and Hamsten, A. and Heinrich, J. and Hingorani, A. and Humphries, S. E. and Jukema, J. W. and Koeing, W. and Kumari, M. and Kutalik, Z. and Lawlor, D. A. and Lehtim{\"a}ki, T. and M{\"a}rz, W. and Mather, K. and Naitza, S. and Nauck, M. and Ohlsson, C. and Price, J. F. and Raitakari, O. and Rice, K. and Sachdev, P. S. and Slagboom, E. and S{\o}rensen, T. I. A. and Spector, T. and Stacey, D. and Stathopoulou, M. G. and Tanaka, T. and Wannamethee, S. G. and Whincup, P. and Rotter, J. I. and Dehghan, A. and Boerwinkle, E. and Psaty, B. M. and Snieder, H. and Alizadeh, B. Z.}
}
@article {9618,
	title = {{Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications},
	journal = {Nat Commun},
	volume = {15},
	year = {2024},
	month = {Jan},
	pages = {888},
	abstract = {T3, whereas the FT4 associations represent the thyroid hormone metabolism. Polygenic risk score and Mendelian randomization analyses showed the effects of genetically determined variation in thyroid function on various clinical outcomes, including cardiovascular risk factors and diseases, autoimmune diseases, and cancer. In conclusion, our results improve the understanding of thyroid hormone physiology and highlight the pleiotropic effects of thyroid function on various diseases.},
	author = {Sterenborg, R. B. T. M. and Steinbrenner, I. and Li, Y. and Bujnis, M. N. and Naito, T. and Marouli, E. and Galesloot, T. E. and Babajide, O. and Andreasen, L. and Astrup, A. and svold, B. O. and Bandinelli, S. and Beekman, M. and Beilby, J. P. and Bork-Jensen, J. and Boutin, T. and Brody, J. A. and Brown, S. J. and Brumpton, B. and Campbell, P. J. and Cappola, A. R. and Ceresini, G. and Chaker, L. and Chasman, D. I. and Concas, M. P. and Coutinho de Almeida, R. and Cross, S. M. and Cucca, F. and Deary, I. J. and Kjaergaard, A. D. and Echouffo Tcheugui, J. B. and Ellervik, C. and Eriksson, J. G. and Ferrucci, L. and Freudenberg, J. and Fuchsberger, C. and Gieger, C. and Giulianini, F. and gele, M. and Graham, S. E. and Grarup, N. and {\"a}, I. and Hansen, T. and Harding, B. N. and Harris, S. E. and {\o}, S. and Hayward, C. and Hui, J. and Ittermann, T. and Jukema, J. W. and Kajantie, E. and Kanters, J. K. and rhus, L. L. and Kiemeney, L. A. L. M. and Kloppenburg, M. and hnel, B. and Lahti, J. and Langenberg, C. and Lapauw, B. and Leese, G. and Li, S. and Liewald, D. C. M. and Linneberg, A. and Lominchar, J. V. T. and Luan, J. and Martin, N. G. and Matana, A. and Meima, M. E. and Meitinger, T. and Meulenbelt, I. and Mitchell, B. D. and llehave, L. T. and Mora, S. and Naitza, S. and Nauck, M. and Netea-Maier, R. T. and Noordam, R. and Nursyifa, C. and Okada, Y. and Onano, S. and Papadopoulou, A. and Palmer, C. N. A. and Pattaro, C. and Pedersen, O. and Peters, A. and Pietzner, M. and ek, O. and Pramstaller, P. P. and Psaty, B. M. and Punda, A. and Ray, D. and Redmond, P. and Richards, J. B. and Ridker, P. M. and Russ, T. C. and Ryan, K. A. and Olesen, M. S. and Schultheiss, U. T. and Selvin, E. and Siddiqui, M. K. and Sidore, C. and Slagboom, P. E. and rensen, T. I. A. and Soto-Pedre, E. and Spector, T. D. and Spedicati, B. and Srinivasan, S. and Starr, J. M. and Stott, D. J. and Tanaka, T. and Torlak, V. and Trompet, S. and Tuhkanen, J. and Uitterlinden, A. G. and van den Akker, E. B. and van den Eynde, T. and van der Klauw, M. M. and van Heemst, D. and Verroken, C. and Visser, W. E. and Vojinovic, D. and lzke, H. and Waldenberger, M. and Walsh, J. P. and Wareham, N. J. and Weiss, S. and Willer, C. J. and Wilson, S. G. and Wolffenbuttel, B. H. R. and Wouters, H. J. C. M. and Wright, M. J. and Yang, Q. and Zemunik, T. and Zhou, W. and Zhu, G. and llner, S. and Smit, J. W. A. and Peeters, R. P. and ttgen, A. and Teumer, A. and Medici, M.}
}
