@article {8519,
	title = {{Relationship of Estimated GFR and Albuminuria to Concurrent Laboratory Abnormalities: An Individual Participant Data Meta-analysis in a Global Consortium},
	journal = {Am J Kidney Dis},
	volume = {73},
	year = {2019},
	month = {02},
	pages = {206{\textendash}217},
	abstract = {Chronic kidney disease (CKD) is complicated by abnormalities that reflect disruption in filtration, tubular, and endocrine functions of the kidney. Our aim was to explore the relationship of specific laboratory result abnormalities and hypertension with the estimated glomerular filtration rate (eGFR) and albuminuria CKD staging framework.\ Cross-sectional individual participant-level analyses in a global consortium.\ 17 CKD and 38 general population and high-risk cohorts.\ Cohorts in the CKD Prognosis Consortium with data for eGFR and albuminuria, as well as a measurement of hemoglobin, bicarbonate, phosphorus, parathyroid hormone, potassium, or calcium, or hypertension.\ Data were obtained and analyzed between July 2015 and January 2018.\ We modeled the association of eGFR and albuminuria with hemoglobin, bicarbonate, phosphorus, parathyroid hormone, potassium, and calcium values using linear regression and with hypertension and categorical definitions of each abnormality using logistic regression. Results were pooled using random-effects meta-analyses.\ The CKD cohorts (n=254,666 participants) were 27\% women and 10\% black, with a mean age of 69 (SD, 12) years. The general population/high-risk cohorts (n=1,758,334) were 50\% women and 2\% black, with a mean age of 50 (16) years. There was a strong graded association between lower eGFR and all laboratory result abnormalities (ORs ranging from 3.27 [95\% CI, 2.68-3.97] to 8.91 [95\% CI, 7.22-10.99] comparing eGFRs of 15 to 29 with eGFRs of 45 to 59mL/min/1.73m2), whereas albuminuria had equivocal or weak associations with abnormalities (ORs ranging from 0.77 [95\% CI, 0.60-0.99] to 1.92 [95\% CI, 1.65-2.24] comparing urinary albumin-creatinine ratio > 300 vs < 30mg/g).\ Variations in study era, health care delivery system, typical diet, and laboratory assays.\ Lower eGFR was strongly associated with higher odds of multiple laboratory result abnormalities. Knowledge of risk associations might help guide management in the heterogeneous group of patients with CKD.},
	author = {Inker, L. A. and Grams, M. E. and Levey, A. S. and Coresh, J. and Cirillo, M. and Collins, J. F. and Gansevoort, R. T. and Gutierrez, O. M. and Hamano, T. and Heine, G. H. and Ishikawa, S. and Jee, S. H. and Kronenberg, F. and Landray, M. J. and Miura, K. and Nadkarni, G. N. and Peralta, C. A. and Rothenbacher, D. and Schaeffner, E. and Sedaghat, S. and Shlipak, M. G. and Zhang, L. and van Zuilen, A. D. and Hallan, S. I. and Kovesdy, C. P. and Woodward, M. and Levin, A. and Astor, B. and Appel, L. and Greene, T. and Chen, T. and Chalmers, J. and Woodward, M. and Arima, H. and Perkovic, V. and Yatsuya, H. and Tamakoshi, K. and Li, Y. and Hirakawa, Y. and Coresh, J. and Matsushita, K. and Grams, M. and Sang, Y. and Polkinghorne, K. and Chadban, S. and Atkins, R. and Levin, A. and Djurdjev, O. and Zhang, L. and Liu, L. and Zhao, M. and Wang, F. and Wang, J. and Schaeffner, E. and Ebert, N. and Martus, P. and Levin, A. and Djurdjev, O. and Tang, M. and Heine, G. and Emrich, I. and Seiler, S. and Zawada, A. and Nally, J. and Navaneethan, S. and Schold, J. and Zhang, L. and Zhao, M. and Wang, F. and Wang, J. and Shlipak, M. and Sarnak, M. and Katz, R. and Hiramoto, J. and Iso, H. and Yamagishi, K. and Umesawa, M. and Muraki, I. and Fukagawa, M. and Maruyama, S. and Hamano, T. and Hasegawa, T. and Fujii, N. and Wheeler, D. and Emberson, J. and Townend, J. and Landray, M. and Brenner, H. and Sch?ttker, B. and Saum, K. U. and Rothenbacher, D. and Fox, C. and Hwang, S. J. and K?ttgen, A. and Kronenberg, F. and Schneider, M. P. and Eckardt, K. U. and Green, J. and Kirchner, H. L. and Chang, A. R. and Ho, K. and Ito, S. and Miyazaki, M. and Nakayama, M. and Yamada, G. and Cirillo, M. and Irie, F. and Sairenchi, T. and Ishikawa, S. and Yano, Y. and Kotani, K. and Nakamura, T. and Jee, S. H. and Kimm, H. and Mok, Y. and Chodick, G. and Shalev, V. and Wetzels, J. F. M. and Blankestijn, P. J. and van Zuilen, A. D. and van den Brand, J. and Sarnak, M. and Inker, L. and Peralta, C. and Hiramoto, J. and Katz, R. and Sarnak, M. and Kronenberg, F. and Kollerits, B. and Ritz, E. and Nitsch, D. and Roderick, P. and Fletcher, A. and Bottinger, E. and Nadkarni, G. N. and Ellis, S. B. and Nadukuru, R. and Sang, Y. and Ueshima, H. and Okayama, A. and Miura, K. and Tanaka, S. and Ueshima, H. and Okamura, T. and Miura, K. and Tanaka, S. and Miura, K. and Okayama, A. and Kadota, A. and Tanaka, S. and Kenealy, T. and Elley, C. R. and Collins, J. F. and Drury, P. L. and Ohkubo, T. and Asayama, K. and Metoki, H. and Kikuya, M. and Nakayama, M. and Nelson, R. G. and Knowler, W. C. and Gansevoort, R. T. and Bakker, S. J. and Hak, E. and Heerspink, H. J. L. and Brunskill, N. and Major, R. and Shepherd, D. and Medcalf, J. and Jassal, S. K. and Bergstrom, J. and Ix, J. H. and Barrett-Connor, E. and Kovesdy, C. and Kalantar-Zadeh, K. and Sumida, K. and Gutierrez, O. M. and Muntner, P. and Warnock, D. and McClellan, W. and Heerspink, H. J. L. and de Zeeuw, D. and Brenner, B. and Sedaghat, S. and Ikram, M. A. and Hoorn, E. J. and Dehghan, A. and Carrero, J. J. and Gasparini, A. and Wettermark, B. and Elinder, C. G. and Wong, T. Y. and Sabanayagam, C. and Cheng, C. Y. and Visseren, F. L. J. and Evans, M. and Segelmark, M. and Stendahl, M. and Sch?n, S. and Tangri, N. and Sud, M. and Naimark, D. and Wen, C. P. and Tsao, C. K. and Tsai, M. K. and Chen, C. H. and Konta, T. and Hirayama, A. and Ichikawa, K. and Lannfelt, L. and Larsson, A. and ?rnl?v, J. and Bilo, H. J. G. and Landman, G. W. D. and van Hateren, K. J. J. and Kleefstra, N. and Coresh Chair, J. and Gansevoort, R. T. and Grams, M. E. and Hallan, S. and Kovesdy, C. P. and Levey, A. S. and Matsushita, K. and Shalev, V. and Woodward, M. and Ballew, S. H. and Chen, J. and Coresh, J. and Grams, M. E. and Kwak, L. and Matsushita, K. and Sang, Y. and Surapaneni, A. and Woodward, M.}
}
@article {9041,
	title = {{Replication study of AD-associated rare variants},
	journal = {Alzheimers Dement},
	volume = {18},
	year = {2022},
	month = {Apr},
	pages = {858{\textendash}862},
	author = {Neupane, A. and Lenny, B. and Budde, J. P. and Wang, F. and Norton, J. and Morris, J. C. and Cruchaga, C. and Fern{\'a}ndez, M. V.}
}
