@article {8781,
	title = {{A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids},
	journal = {Nat Commun},
	volume = {12},
	year = {2021},
	month = {06},
	pages = {3987},
	abstract = {10.1038/s41467-021-23899-yHere we examine the association between DNA methylation in circulating leukocytes and blood lipids in a multi-ethnic sample of 16,265 subjects. We identify 148, 35, and 4 novel associations among Europeans, African Americans, and Hispanics, respectively, and an additional 186 novel associations through a trans-ethnic meta-analysis. We observe a high concordance in the direction of effects across racial/ethnic groups, a high correlation of effect sizes between high-density lipoprotein and triglycerides, a modest overlap of associations with epigenome-wide association studies of other cardio-metabolic traits, and a largely non-overlap with lipid loci identified to date through genome-wide association studies. Thirty CpGs reached significance in at least 2 racial/ethnic groups including 7 that showed association with the expression of an annotated gene. CpGs annotated to CPT1A showed evidence of being influenced by triglycerides levels. DNA methylation levels of circulating leukocytes show robust and consistent association with blood lipid levels across multiple racial/ethnic groups.},
	author = {Jhun, M. A. and Mendelson, M. and Wilson, R. and Gondalia, R. and Joehanes, R. and Salfati, E. and Zhao, X. and Braun, K. V. E. and Do, A. N. and Hedman, {\r A}. K. and Zhang, T. and Carnero-Montoro, E. and Shen, J. and Bartz, T. M. and Brody, J. A. and Montasser, M. E. and O{\textquoteright}Connell, J. R. and Yao, C. and Xia, R. and Boerwinkle, E. and Grove, M. and Guan, W. and Liliane, P. and Singmann, P. and M{\"u}ller-Nurasyid, M. and Meitinger, T. and Gieger, C. and Peters, A. and Zhao, W. and Ware, E. B. and Smith, J. A. and Dhana, K. and van Meurs, J. and Uitterlinden, A. and Ikram, M. A. and Ghanbari, M. and Zhi, D. and Gustafsson, S. and Lind, L. and Li, S. and Sun, D. and Spector, T. D. and Chen, Y. I. and Damcott, C. and Shuldiner, A. R. and Absher, D. M. and Horvath, S. and Tsao, P. S. and Kardia, S. and Psaty, B. M. and Sotoodehnia, N. and Bell, J. T. and Ingelsson, E. and Chen, W. and Dehghan, A. and Arnett, D. K. and Waldenberger, M. and Hou, L. and Whitsel, E. A. and Baccarelli, A. and Levy, D. and Fornage, M. and Irvin, M. R. and Assimes, T. L.}
}
@article {9111,
	title = {{DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases},
	journal = {Nat Commun},
	volume = {13},
	year = {2022},
	month = {05},
	pages = {2408},
	abstract = {We performed a multi-ethnic Epigenome Wide Association study on 22,774 individuals to describe the DNA methylation signature of chronic low-grade inflammation as measured by C-Reactive protein (CRP). We find 1,511 independent differentially methylated loci associated with CRP. These CpG sites show correlation structures across chromosomes, and are primarily situated in euchromatin, depleted in CpG islands. These genomic loci are predominantly situated in transcription factor binding sites and genomic enhancer regions. Mendelian randomization analysis suggests altered CpG methylation is a consequence of increased blood CRP levels. Mediation analysis reveals obesity and smoking as important underlying driving factors for changed CpG methylation. Finally, we find that an activated CpG signature significantly increases the risk for cardiometabolic diseases and COPD.},
	author = {Wielscher, M. and Mandaviya, P. R. and Kuehnel, B. and Joehanes, R. and Mustafa, R. and Robinson, O. and Zhang, Y. and Bodinier, B. and Walton, E. and Mishra, P. P. and Schlosser, P. and Wilson, R. and Tsai, P. C. and Palaniswamy, S. and Marioni, R. E. and Fiorito, G. and Cugliari, G. and Karhunen, V. and Ghanbari, M. and Psaty, B. M. and Loh, M. and Bis, J. C. and Lehne, B. and Sotoodehnia, N. and Deary, I. J. and Chadeau-Hyam, M. and Brody, J. A. and Cardona, A. and Selvin, E. and Smith, A. K. and Miller, A. H. and Torres, M. A. and Marouli, E. and G{\`a}o, X. and van Meurs, J. B. J. and Graf-Schindler, J. and Rathmann, W. and Koenig, W. and Peters, A. and Weninger, W. and Farlik, M. and Zhang, T. and Chen, W. and Xia, Y. and Teumer, A. and Nauck, M. and Grabe, H. J. and Doerr, M. and Lehtim{\"a}ki, T. and Guan, W. and Milani, L. and Tanaka, T. and Fisher, K. and Waite, L. L. and Kasela, S. and Vineis, P. and Verweij, N. and van der Harst, P. and Iacoviello, L. and Sacerdote, C. and Panico, S. and Krogh, V. and Tumino, R. and Tzala, E. and Matullo, G. and Hurme, M. A. and Raitakari, O. T. and Colicino, E. and Baccarelli, A. A. and K{\"a}h{\"o}nen, M. and Herzig, K. H. and Li, S. and Conneely, K. N. and Kooner, J. S. and K{\"o}ttgen, A. and Heijmans, B. T. and Deloukas, P. and Relton, C. and Ong, K. K. and Bell, J. T. and Boerwinkle, E. and Elliott, P. and Brenner, H. and Beekman, M. and Levy, D. and Waldenberger, M. and Chambers, J. C. and Dehghan, A. and Jarvelin, M. R.}
}
