@article {9458,
	title = {n-3 Fatty Acid Biomarkers and Incident Type 2 Diabetes: An Individual Participant-Level Pooling Project of 20 Prospective Cohort Studies},
	journal = {Diabetes Care},
	volume = {44},
	year = {2021},
	month = {May},
	pages = {1133{\textendash}1142},
	abstract = {-linolenic acid (ALA), eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA) with T2D risk through an individual participant-level pooled analysis.\ For our analysis we incorporated data from a global consortium of 20 prospective studies from 14 countries. We included 65,147 participants who had blood measurements of ALA, EPA, DPA, or DHA and were free of diabetes at baseline. De novo harmonized analyses were performed in each cohort following a prespecified protocol, and cohort-specific associations were pooled using inverse variance-weighted meta-analysis.\ 0.001). ALA was not associated with T2D (HR 0.97 [95\% CI 0.92, 1.02]) per interquintile range. Associations were robust across prespecified subgroups as well as in sensitivity analyses.\ Higher circulating biomarkers of seafood-derived n-3 fatty acids, including EPA, DPA, DHA, and their sum, were associated with lower risk of T2D in a global consortium of prospective studies. The biomarker of plant-derived ALA was not significantly associated with T2D risk.},
	author = {Qian, F. and Ardisson Korat, A. V. and Imamura, F. and Marklund, M. and Tintle, N. and Virtanen, J. K. and Zhou, X. and Bassett, J. K. and Lai, H. and Hirakawa, Y. and Chien, K. L. and Wood, A. C. and Lankinen, M. and Murphy, R. A. and Samieri, C. and Pertiwi, K. and de Mello, V. D. and Guan, W. and Forouhi, N. G. and Wareham, N. and Hu, I. C. F. B. and Riserus, U. and Lind, L. and Harris, W. S. and Shadyab, A. H. and Robinson, J. G. and Steffen, L. M. and Hodge, A. and Giles, G. G. and Ninomiya, T. and Uusitupa, M. and Tuomilehto, J. and m, J. and Laakso, M. and Siscovick, D. S. and Helmer, C. and Geleijnse, J. M. and Wu, J. H. Y. and Fretts, A. and Lemaitre, R. N. and Micha, R. and Mozaffarian, D. and Sun, Q.}
}
@article {9460,
	title = {{Trans Fatty Acid Biomarkers and Incident Type 2 Diabetes: Pooled Analysis of 12 Prospective Cohort Studies in the Fatty Acids and Outcomes Research Consortium (FORCE)},
	journal = {Diabetes Care},
	volume = {45},
	year = {2022},
	month = {Apr},
	pages = {854{\textendash}863},
	abstract = {Trans fatty acids (TFAs) have harmful biologic effects that could increase the risk of type 2 diabetes (T2D), but evidence remains uncertain. We aimed to investigate the prospective associations of TFA biomarkers and T2D by conducting an individual participant-level pooled analysis.\ 18 years without prevalent diabetes. Each cohort conducted de novo harmonized analyses using a prespecified protocol, and findings were pooled using inverse-variance weighted meta-analysis. Heterogeneity was explored by prespecified between-study and within-study characteristics.\ 0.1).\ Circulating individual trans-18:2 TFA biomarkers were not associated with risk of T2D, while trans-16:1n-9, total trans-18:1, and total trans-18:2 were inversely associated. Findings may reflect the influence of mixed TFA sources (industrial vs. natural ruminant), a general decline in TFA exposure due to policy changes during this period, or the relatively limited range of TFA levels.},
	author = {Lai, H. T. M. and Imamura, F. and Korat, A. V. A. and Murphy, R. A. and Tintle, N. and Bassett, J. K. and Chen, J. and ger, J. and Chien, K. L. and Senn, M. and Wood, A. C. and Forouhi, N. G. and Schulze, M. B. and Harris, W. S. and Vasan, R. S. and Hu, F. and Giles, G. G. and Hodge, A. and Djousse, L. and Brouwer, I. A. and Qian, F. and Sun, Q. and Wu, J. H. Y. and Marklund, M. and Lemaitre, R. N. and Siscovick, D. S. and Fretts, A. M. and Shadyab, A. H. and Manson, J. E. and Howard, B. V. and Robinson, J. G. and Wallace, R. B. and Wareham, N. J. and Chen, Y. I. and Rotter, J. I. and Tsai, M. Y. and Micha, R. and Mozaffarian, D.}
}
