@article {9859,
	title = {Alzheimer{\textquoteright}s Disease Sequencing Project Release 4 Whole Genome Sequencing Dataset},
	journal = {medRxiv},
	year = {2024},
	month = {Dec},
	abstract = {The Alzheimer{\textquoteright}s Disease Sequencing Project (ADSP) is a national initiative to understand the genetic architecture of Alzheimer{\textquoteright}s Disease and Related Dementias (AD/ADRD) by sequencing whole genomes of affected participants and age-matched cognitive controls from diverse populations. The Genome Center for Alzheimer{\textquoteright}s Disease (GCAD) processed whole-genome sequencing data from 36,361 ADSP participants, including 35,014 genetically unique participants of which 45\% are from non-European ancestry, across 17 cohorts in 14 countries in this fourth release (R4). This sequencing effort identified 387 million bi-allelic variants, 42 million short insertions/deletions, and 2.2 million structural variants. Annotations and quality control data are available for all variants and samples. Additionally, detailed phenotypes from 15,927 participants across 10 domains are also provided. A linkage disequilibrium panel was created using unrelated AD cases and controls. Researchers can access and analyze the genetic data via NIAGADS Data Sharing Service, the VariXam tool, or NIAGADS GenomicsDB.},
	author = {Leung, Y. Y. and Lee, W. P. and Kuzma, A. B. and Nicaretta, H. and Valladares, O. and Gangadharan, P. and Qu, L. and Zhao, Y. and Ren, Y. and Cheng, P. L. and Kuksa, P. P. and Wang, H. and White, H. and Katanic, Z. and Bass, L. and Saravanan, N. and Greenfest-Allen, E. and Kirsch, M. and Cantwell, L. and Iqbal, T. and Wheeler, N. R. and Farrell, J. J. and Zhu, C. and Turner, S. L. and Gunasekaran, T. I. and Mena, P. R. and Jin, J. and Carter, L. and Zhang, X. and Vardarajan, B. N. and Toga, A. and Cuccaro, M. and Hohman, T. J. and Bush, W. S. and Naj, A. C. and Martin, E. and Dalgard, C. and Kunkle, B. W. and Farrer, L. A. and Mayeux, R. P. and Haines, J. L. and Pericak-Vance, M. A. and Schellenberg, G. D. and Wang, L. S.}
}
@article {9639,
	title = {{Genetic associations with dementia-related proteinopathy: Application of item response theory},
	journal = {Alzheimers Dement},
	year = {2024},
	month = {Mar},
	abstract = {Although dementia-related proteinopathy has a strong negative impact on public health, and is highly heritable, understanding of the related genetic architecture is incomplete.\ -synuclein, and TDP-43.\ -synuclein/Lewy bodies. Novel suggestive proteinopathy-linked alleles were also discovered, including several (SDHAF1, TMEM68, and ARHGEF28) with colocalization analyses and/or high degrees of biologic credibility.\ A novel methodology using GPCM enabled insights into gene candidates for driving misfolded proteinopathies.\ Latent factor scores for proteinopathies were estimated using a generalized partial credit model. The three latent continuous scores corresponded well with proteinopathy severity. Novel genes associated with proteinopathies were identified. Several genes had high degrees of biologic credibility for dementia risk factors.},
	author = {Katsumata, Y. and Fardo, D. W. and Shade, L. M. P. and Wu, X. and Karanth, S. D. and Hohman, T. J. and Schneider, J. A. and Bennett, D. A. and Farfel, J. M. and Gauthreaux, K. and Mock, C. and Kukull, W. A. and Abner, E. L. and Nelson, P. T. and Carrillo, M. and Reiman, E. M. and Chen, K. and Masterman, D. and Green, R. C. and Ho, C. and Fleisher, A. and Saykin, A. J. and Nho, K. and Apostolova, L. G. and Risacher, S. L. and Jackson, J. and Forghanian-Arani, A. and Borowski, B. and Ward, C. and Schwarz, C. and Jack, C. R. and Jones, D. and Gunter, J. and Kantarci, K. and Senjem, M. and Vemuri, P. and Reid, R. and Petersen, R. and Hsiao, J. K. and Potter, W. and Masliah, E. and Hsiao, J. K. and Ryan, L. and Bernard, M. and Silverberg, N. and Kormos, A. and Conti, C. and Veitch, D. and Flenniken, D. and Sacrey, D. T. and Choe, M. and Ashford, M. and Chen, S. R. and Faber, K. and Nudelman, K. and Wilme, K. and Foroud, T. M. and Trojanowki, J. Q. and Shaw, L. M. and Korecka, M. and Figurski, M. and Khachaturian, Z. and Barnes, L. and Malone, I. and Fox, N. C. and Beckett, L. and Weiner, M. W. and Jagust, W. and Landau, S. and Jagust, W. and Knaack, A. and DeCarli, C. and Harvey, D. and Fletcher, E. and Beckett, L. and lez, H. and Jin, C. and Tosun-Turgut, D. and Neuhaus, J. and Fockler, J. and Nosheny, R. and Koeppe, R. A. and Trojanowki, J. Q. and Shaw, L. M. and Yushkevich, P. A. and Das, S. and Mathis, C. and Toga, A. W. and Zimmerman, C. and Gessert, D. and Shcrer, E. and Miller, G. and Coker, G. and Jimenez, G. and Salazar, J. and Pizzola, J. and Crawford, K. and Hergesheimer, L. and Donohue, M. and Rafii, M. and Adegoke, O. and Aisen, P. and Mahboubi, P. and Raman, R. and Walter, S. and Neu, S. and Moore, S. and Smith, S. and Clanton, T. and Cabrera, Y. and Donohue, M. and Jahanshad, N. and Thompson, P. and Thomopoulos, S. I. and Nir, T. M. and Crawford, K. and Montine, T. and Okonkwo, O. and Shen, L. and Perrin, R. and Franklin, E. and Householder, E. and Bernhardt, H. and Morris, J. C. and Taylor-Reinwald, L. and Cairns, N. J. and Perrin, R. J. and Biber, S. and Welsch, J. and Rosentreter, H. and Fair, B. and Young, A. and Hale, B. and Hockens, V. and Buckley, F. and Ida, A. and Xia, J. and Almeda, E. and Stephens, K. A. and Shibata, D. K. and Chan, K. C. G. and Longstreth, W. and Che, Y. C. and Culhane, J. and Miller, Z. and Yasuda, S. and Mooney, S. and Hubbard, J. and Keller, B. and Stark, Z. and Wu, J. and Mcleod, L. and Hewanadungodage, C. and Smith, B.}
}
