@article {9864, title = {Sleep macro-architecture and dementia risk in adults: Meta-analysis of 5 cohorts from the Sleep and Dementia Consortium.}, journal = {medRxiv}, year = {2024}, month = {2024 Nov 05}, abstract = {

STUDY OBJECTIVES: Poor sleep may play a role in the risk of dementia. However, few studies have investigated the association between polysomnography (PSG)-derived sleep architecture and dementia incidence. We examined the relationship between sleep macro-architecture and dementia incidence across five US-based cohort studies from the Sleep and Dementia Consortium (SDC).

METHODS: Percent of time spent in stages of sleep (N1, N2, N3, REM sleep), wake after sleep onset and sleep maintenance efficiency were derived from a single night home-based PSG. Dementia was ascertained in each cohort using its cohort-specific criteria. Each cohort performed Cox proportional hazard regressions for each sleep exposure and incident dementia, adjusting for age, sex, body mass index, anti-depressant use, sedative use, and status. Results were then pooled in random effects meta-analyses.

RESULTS: The pooled sample comprised 4,657 participants (30\% women) aged >=60 years (mean age was 74 years at sleep assessment). There were 998 (21.4\%) dementia cases (median follow-up time of 5 to 19 years). Pooled effects of the five cohorts showed no association between sleep architecture and incident dementia. When meta-analyses were restricted to the three cohorts which had dementia case ascertainment based on DSM-IV/V criteria (n=2,374), higher N3\% was marginally associated with an increased risk of dementia (HR: 1.06; 95\%CI: 1.00-1.12, per percent increase N3, p=0.050).

CONCLUSIONS: There were no consistent associations between sleep macro-architecture measured and the risk of incident dementia. Implementing more nuanced sleep metrics remains an important next step for uncovering more about sleep-dementia associations.

}, doi = {10.1101/2024.11.05.24316677}, author = {Yiallourou, Stephanie and Baril, Andree-Ann and Wiedner, Crystal and Misialek, Jeffrey R and Kline, Christopher E and Harrison, Stephanie and Cannon, Ethan and Yang, Qiong and Bernal, Rebecca and Bisson, Alycia and Himali, Dibya and Cavuoto, Marina and Weihs, Antoine and Beiser, Alexa and Gottesman, Rebecca F and Leng, Yue and Lopez, Oscar and Lutsey, Pamela L and Purcell, Shaun M and Redline, Susan and Seshadri, Sudha and Stone, Katie L and Yaffe, Kristine and Ancoli-Israel, Sonia and Xiao, Qian and Vaou, Eleni Okeanis and Himali, Jayandra J and Pase, Matthew P} }