@article {9903,
	title = {A multi-cohort genome-wide association study in African ancestry individuals reveals risk loci for primary open-angle glaucoma.},
	journal = {Cell},
	volume = {187},
	year = {2024},
	month = {2024 Jan 18},
	pages = {464-480.e10},
	abstract = {<p>Primary open-angle glaucoma (POAG), the leading cause of irreversible blindness worldwide, disproportionately affects individuals of African ancestry. We conducted a genome-wide association study (GWAS) for POAG in 11,275 individuals of African ancestry (6,003 cases; 5,272 controls). We detected 46 risk loci associated with POAG at genome-wide significance. Replication and post-GWAS analyses, including functionally informed fine-mapping, multiple trait co-localization, and in silico validation, implicated two previously undescribed variants (rs1666698 mapping to DBF4P2; rs34957764 mapping to ROCK1P1) and one previously associated variant (rs11824032 mapping to ARHGEF12) as likely causal. For individuals of African ancestry, a polygenic risk score (PRS) for POAG from our mega-analysis (African ancestry individuals) outperformed a PRS from summary statistics of a much larger GWAS derived from European ancestry individuals. This study quantifies the genetic architecture similarities and differences between African and non-African ancestry populations for this blinding disease.</p>},
	keywords = {Black People, Genetic Predisposition to Disease, Genome-Wide Association Study, Glaucoma, Open-Angle, Humans, Polymorphism, Single Nucleotide},
	issn = {1097-4172},
	doi = {10.1016/j.cell.2023.12.006},
	author = {Verma, Shefali S and Gudiseva, Harini V and Chavali, Venkata R M and Salowe, Rebecca J and Bradford, Yuki and Guare, Lindsay and Lucas, Anastasia and Collins, David W and Vrathasha, Vrathasha and Nair, Rohini M and Rathi, Sonika and Zhao, Bingxin and He, Jie and Lee, Roy and Zenebe-Gete, Selam and Bowman, Anita S and McHugh, Caitlin P and Zody, Michael C and Pistilli, Maxwell and Khachatryan, Naira and Daniel, Ebenezer and Murphy, Windell and Henderer, Jeffrey and Kinzy, Tyler G and Iyengar, Sudha K and Peachey, Neal S and Taylor, Kent D and Guo, Xiuqing and Chen, Yii-Der Ida and Zangwill, Linda and Girkin, Christopher and Ayyagari, Radha and Liebmann, Jeffrey and Chuka-Okosa, Chimd M and Williams, Susan E and Akafo, Stephen and Budenz, Donald L and Olawoye, Olusola O and Ramsay, Michele and Ashaye, Adeyinka and Akpa, Onoja M and Aung, Tin and Wiggs, Janey L and Ross, Ahmara G and Cui, Qi N and Addis, Victoria and Lehman, Amanda and Miller-Ellis, Eydie and Sankar, Prithvi S and Williams, Scott M and Ying, Gui-Shuang and Cooke Bailey, Jessica and Rotter, Jerome I and Weinreb, Robert and Khor, Chiea Chuen and Hauser, Michael A and Ritchie, Marylyn D and O{\textquoteright}Brien, Joan M}
}
