@article {9939,
	title = {Plasma TAR DNA-binding protein 43 (TDP-43) levels in a population-based cohort of older adults: The cardiovascular health study.},
	journal = {J Alzheimers Dis},
	year = {2025},
	month = {2025 Apr 23},
	pages = {13872877251334820},
	abstract = {<p>Brain deposition of transactive response DNA-binding protein 43 (TDP-43) is a feature of neurodegenerative syndromes. We evaluated TDP-43 plasma concentrations in 1058 participants in the Cardiovascular Health Study (CHS), a population-based longitudinal cohort. The cohort was 38\% male, 11\% Black, had a mean age 75 years, and 261 people developed dementia over a mean of 5.5 years of follow up. Median TDP-43 levels were 211.0 pg/mL (IQR: 134.0-341.0 pg/mL). TDP-43 levels were not associated with cross-sectional or longitudinal change in cognitive scores, with plasma AD biomarkers, with brain MRI volumes, with incident dementia, or with demographic characteristics.</p>},
	issn = {1875-8908},
	doi = {10.1177/13872877251334820},
	author = {Fohner, Alison E and Sitlani, Colleen M and Jayadev, Suman and Bis, Joshua C and Trittschuh, Emily H and Lopez, Oscar L and Tracy, Russel P and Psaty, Bruce M and Longstreth, W T and Seshadri, Sudha}
}
