@article {9981, title = {Association of Immune Cell Subsets With Longevity: The Cardiovascular Health Study.}, journal = {J Gerontol A Biol Sci Med Sci}, volume = {80}, year = {2025}, month = {2025 Jun 10}, abstract = {

BACKGROUND: Changes in the immune system are a potential biological mechanism of aging. We investigated the association of circulating immune cell subsets with age at death and survival to age 90.

METHODS: Immune cell phenotypes were measured at baseline in 1 625 adults, aged 70-85 years, in the Cardiovascular Health Study. We selected 5 primary immune cell subsets: gamma-delta T-cells, natural killer cells, CD8+ T effector memory CD45RA expressing cells(TEMRA) cells, ratio of CD4+ to CD8+ cells, and ratio of na{\"\i}ve to memory CD8+ cells. We used linear regression and Poisson models, adjusting for demographics and clinical factors; and tested for effect modification by sex and race. In a secondary analysis, we investigated 23 additional immune cell subsets, using the Holm-Bonferroni method to adjust for multiple comparisons.

RESULTS: No primary immune cell subsets were significantly associated with longevity. Two secondary subsets were significantly associated with age at death. Each SD higher proportion of CD4+CD57+ cells was associated with a 0.64-year earlier death (95\% CI: -0.99, -0.30) and each SD higher proportion of CD4+CD28-CD57+ cells was associated with a 0.54-year earlier death (95\% CI: -0.87, -0.21). Several subsets had significant interactions with sex and race in the fully adjusted model of age at death. A higher proportion of CD4+CD57+ T-cells was significantly associated with lower likelihood of survival to age 90 (relative risk: 0.79) and 1.07-year earlier age at death in males, but not in females.

CONCLUSIONS: Our results suggest that CD4+CD57+ cells are associated with earlier death and this relationship was stronger in males than females.

}, keywords = {Aged, Aged, 80 and over, Aging, Cardiovascular Diseases, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Female, Humans, Killer Cells, Natural, Longevity, Male}, issn = {1758-535X}, doi = {10.1093/gerona/glaf094}, author = {Dobrota Lai, Sylvie and B{\r u}zkov{\'a}, Petra and Delaney, Joseph A and Olson, Nels C and Psaty, Bruce M and Huber, Sally A and Doyle, Margaret F and Tracy, Russell P and Odden, Michelle C} }