@proceedings {1526,
	title = {Respondent Burden in Studies of the Elderly: Experience from the Cardiovascular Health Study (CHS)},
	year = {1992},
	month = {1993-01-01},
	pages = {135-152},
	publisher = {Marion Merrell Dow Inc},
	abstract = {ACC Workshop entitled "Inclusion of Elderly Individuals in Clinical Trials" September 15-16, 1992},
	keywords = {Health, respondent burden},
	author = {Manolio, TA and Hermanson, B and Hill, J and Meyer, M and Cruise, G and Anton-Culver, H}
}
@article {1527,
	title = {Classification accuracy of electrocardiographic criteria for left ventricular hypertrophy in normal weight and overweight older adults: the Cardiovascular Health Study},
	journal = {Annals of Noninvasive Electrocardiology},
	volume = {1},
	year = {1996},
	month = {1996-01-01},
	pages = {132},
	chapter = {121},
	abstract = {BACKGROUND We evaluated classification accuracy of ECG criteria at varying levels of left ventricular hypertrophy (LVH) severity according to echocardiographically measured left ventricular mass (LVM) adjusted body size. METHODS: The test population was derived from the Cardiovascular Health Study (CHS), a population based sample of 5201 men and women aged 65 and older, and consisted of 1844 women and 1119 men with adequate quality ECGs and echocardiograms for LVM determination. The criteria evaluated were Sokolow-Lyon, Cornell Voltage, Cornell product, Framingham modification of Cornell voltage, and the left ventricular mass index (LVMI) of the Novacode ECG program. RESULTS: With LVH thresholds at upper 95\% normal limit for weight adjusted LVM for the CHS population and ECG thresholds adjusted for 95\% specificity in normal weight and overweight subgroups, the sensitivity of ECG criteria for LVH was relatively low. it was highest (40.8\%) for the Novacode LVMI in normal weight men and for the Framingham criteria (30.9\%) in normal weight women, but it deteriorated for both of these criteria in the presence of obesity. The overall performance of the Cornell product and Cornell voltage criteria was least influenced by obesity. The Framingham adjustment for the Cornell Voltage criteria for obesity substantially reduced their sensitivity. CONCLUSION: The choice of echocardiographic standard, LVH severity level and overweight in the test groups have a strong influence on ECG evaluation results.},
	keywords = {Adult, Aged, Body Size, classification, Health, Hypertrophy, methods, Obesity, Population},
	author = {Rautaharju, PM and Manolio, TA and Siscovick, D and Zhou, SH and Gardin, JM and Furberg, CD and Borhani, NO and Newman, AB}
}
@article {1528,
	title = {Neurologic correlates of infarction-like lesion location on magnetic resonance imaging in the cardiovascular health study},
	journal = {J. Stroke Cerebrovascular Disease},
	volume = {9},
	year = {2000},
	month = {2000-01-01},
	pages = {228},
	chapter = {218},
	abstract = {Objective: To evaluate and quantify the associations of infarction-like lesion location in the brain with cognitive and physical impairment in an elderly population. Methods: Data from magnetic resonance imaging (MRI) scans for 3647 Cardiovascular Health Study participants were analyzed. Associations between infarction-like lesion location and various neurologic and performance-based measurements were assessed by using regression models. Continuous responses were expressed in percentiles. Models excluding participants with a history of stroke were also examined. Results: Brainstem infarction-like lesions were associated with a severely reduced Mini-Mental State Examination score (difference [d] = 15 percentiles, P < .001), reduced digit-symbol score (d = 12 percentiles, P < .01), increased time to walk 15 feet (d = 15 percentiles, P < .001), and increased odds of a history of dizziness (odds ratio [OR] = 2.5, P <.01). Basal ganglia infarctions were associated with an increased prevalence of visual field deficits (OR = 1.8, P <.001), and cerebellar white matter infarction-like lesions with an increased prevalence of a history of coma (OR = 4.0, P < .01). For those with infarction-like lesions in both the cerebral cortex and brainstem, the degree of sleepiness was substantially elevated (d = 34 percentiles, P < .01). No associations with a history of migraines were detected. After exclusion of those with stroke history, all of these associations persisted. Conclusion: The estimated magnitude and statistical significance of these associations relative to those with no infarction-like lesions provides new information. Further investigation for some of the associations, such as the role of the brainstem in cognitive function and the association of basal ganglia infarction-like lesions with visual field deficits, would be worthwhile.},
	keywords = {basal, Brain, Cerebral Cortex, ganglia, Health, history, Infarction, Magnetic Resonance Imaging, methods, Odds Ratio, Population, Prevalence, Stroke},
	author = {McClelland, RL and Kronmal, RA and Bryan, RN and Manolio, TA and Herskovits, EH and Kuller, LH and O{\textquoteright}Leary, DH}
}
