@article {7366, title = {Association of DPP-4 activity with BMD, body composition, and incident hip fracture: the Cardiovascular Health Study.}, journal = {Osteoporos Int}, volume = {28}, year = {2017}, month = {2017 May}, pages = {1631-1640}, abstract = {

There was no association of plasma DPP-4 activity levels with bone mineral density (BMD), body composition, or incident hip fractures in a cohort of elderly community-dwelling adults.

INTRODUCTION: Dipeptidyl peptidase IV (DPP-4) inactivates several key hormones including those that stimulate postprandial insulin secretion, and DPP-4 inhibitors (gliptins) are approved to treat diabetes. While DPP-4 is known to modulate osteogenesis, the relationship between DPP-4 activity and skeletal health is uncertain. The purpose of the present study was to examine possible associations between DPP-4 activity in elderly subjects enrolled in the Cardiovascular Health Study (CHS) and BMD, body composition measurements, and incident hip fractures.

METHODS: All 1536 male and female CHS participants who had evaluable DXA scans and plasma for DPP-4 activity were included in the analyses. The association between (1) BMD of the total hip, femoral neck, lumbar spine, and total body; (2) body composition measurements (\% lean, \% fat, and total body mass); and (3) incident hip fractures and plasma levels of DPP-4 activity were determined.

RESULTS: Mean plasma levels of DPP-4 activity were significantly higher in blacks (227~{\textpm}~78) compared with whites (216~{\textpm}~89) (p~=~0.04). However, there was no significant association of DPP-4 activity with age or gender (p~>=~0.14 for both). In multivariable adjusted models, there was no association of plasma DPP-4 activity with BMD overall (p~>=~0.55 for all) or in gender stratified analyses (p~>=~0.23). There was also no association of DPP-4 levels and incident hip fractures overall (p~>=~0.24) or in gender stratified analyses (p~>=~0.39).

CONCLUSION: Plasma DPP-4 activity, within the endogenous physiological range, was significantly associated with race, but not with BMD, body composition, or incident hip fractures in elderly community-dwelling subjects.

}, issn = {1433-2965}, doi = {10.1007/s00198-017-3916-4}, author = {Carbone, L D and B{\r u}{\v z}kov{\'a}, P and Fink, H A and Robbins, J A and Bethel, M and Isales, C M and Hill, W D} }