02134nas a2200253   4500008004100000022001400041245014600055210006900201260000900270300001100279490000700290520132900297653002301626653002501649653002501674653002101699653001501720653001101735653001701746653002601763653002001789110003501809856003601844       2008                        eng d  a0393-299000aCollaborative pooled analysis of data on C-reactive protein gene variants and coronary disease: judging causality by Mendelian randomisation.0 aCollaborative pooled analysis of data on Creactive protein gene   c2008  a531-400 v233 a<p>Many prospective studies have reported associations between circulating C-reactive protein (CRP) levels and risk of coronary heart disease (CHD), but causality remains uncertain. Studies of CHD are being conducted that involve measurement of common polymorphisms of the CRP gene known to be associated with circulating concentrations, thereby utilising these variants as proxies for circulating CRP levels. By analysing data from several studies examining the association between relevant CRP polymorphisms and CHD risk, the present collaboration will undertake a Mendelian randomisation analysis to help assess the likelihood of any causal relevance of CRP levels to CHD risk. A central database is being established containing individual data on CRP polymorphisms, circulating CRP levels, and major coronary outcomes as well as age, sex and other relevant characteristics. Associations between CRP polymorphisms or haplotypes and CHD will be evaluated under different circumstances. This collaboration comprises, at present, about 37,000 CHD outcomes and about 120,000 controls, which should yield suitably precise findings to help judge causality. This work should advance understanding of the relevance of low-grade inflammation to CHD and indicate whether or not CRP itself is involved in long-term pathogenesis.</p>10aC-Reactive Protein10aCase-Control Studies10aCooperative Behavior10aCoronary Disease10aHaplotypes10aHumans10aInflammation10aPolymorphism, Genetic10aResearch Design1 aCRP CHD Genetics Collaboration  uhttps://chs-nhlbi.org/node/1026