04908nas a2200757 4500008004100000022001400041245014800055210006900203260001600272300001800288490000800306520264500314653000902959653001102968653004902979653004903028653004803077653003303125653003403158653000903192653001603201653002403217653002403241653001703265653001703282100002203299700002003321700001803341700002003359700002003379700002303399700002003422700001403442700001903456700002503475700001803500700002003518700002203538700002003560700001703580700001803597700002703615700002303642700002403665700002403689700002003713700002403733700002403757700002803781700002403809700002103833700002303854700002103877700001803898700002103916700002303937700001803960700001603978700002203994700001904016700001904035700002104054700002204075700001704097856003604114 2008 eng d a1539-370400aInsulin-like growth factors, their binding proteins, and prostate cancer risk: analysis of individual patient data from 12 prospective studies.0 aInsulinlike growth factors their binding proteins and prostate c c2008 Oct 07 a461-71, W83-80 v1493 a
BACKGROUND: Some, but not all, published results have shown an association between circulating blood levels of some insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) and the subsequent risk for prostate cancer.
PURPOSE: To assess the association between levels of IGFs and IGFBPs and the subsequent risk for prostate cancer.
DATA SOURCES: Studies identified in PubMed, Web of Science, and CancerLit.
STUDY SELECTION: The principal investigators of all studies that published data on circulating concentrations of sex steroids, IGFs, or IGFBPs and prostate cancer risk using prospectively collected blood samples were invited to collaborate.
DATA EXTRACTION: Investigators provided individual participant data on circulating concentrations of IGF-I, IGF-II, IGFBP-II, and IGFBP-III and participant characteristics to a central data set in Oxford, United Kingdom.
DATA SYNTHESIS: The study included data on 3700 men with prostate cancer and 5200 control participants. On average, case patients were 61.5 years of age at blood collection and received a diagnosis of prostate cancer 5 years after blood collection. The greater the serum IGF-I concentration, the greater the subsequent risk for prostate cancer (odds ratio [OR] in the highest vs. lowest quintile, 1.38 [95% CI, 1.19 to 1.60]; P < 0.001 for trend). Neither IGF-II nor IGFBP-II concentrations were associated with prostate cancer risk, but statistical power was limited. Insulin-like growth factor I and IGFBP-III were correlated (r = 0.58), and although IGFBP-III concentration seemed to be associated with prostate cancer risk, this was secondary to its association with IGF-I levels. Insulin-like growth factor I concentrations seemed to be more positively associated with low-grade than high-grade disease; otherwise, the association between IGFs and IGFBPs and prostate cancer risk had no statistically significant heterogeneity related to stage or grade of disease, time between blood collection and diagnosis, age and year of diagnosis, prostate-specific antigen level at recruitment, body mass index, smoking, or alcohol intake.
LIMITATIONS: Insulin-like growth factor concentrations were measured in only 1 sample for each participant, and the laboratory methods to measure IGFs differed in each study. Not all patients had disease stage or grade information, and the diagnosis of prostate cancer may differ among the studies.
CONCLUSION: High circulating IGF-I concentrations are associated with a moderately increased risk for prostate cancer.
10aAged10aHumans10aInsulin-Like Growth Factor Binding Protein 210aInsulin-Like Growth Factor Binding Protein 310aInsulin-Like Growth Factor Binding Proteins10aInsulin-Like Growth Factor I10aInsulin-Like Growth Factor II10aMale10aMiddle Aged10aProspective Studies10aProstatic Neoplasms10aRisk Factors10aSomatomedins1 aRoddam, Andrew, W1 aAllen, Naomi, E1 aAppleby, Paul1 aKey, Timothy, J1 aFerrucci, Luigi1 aCarter, Ballentine1 aMetter, Jeffrey1 aChen, Chu1 aWeiss, Noel, S1 aFitzpatrick, Annette1 aHsing, Ann, W1 aLacey, James, V1 aHelzlsouer, Kathy1 aRinaldi, Sabina1 aRiboli, Elio1 aKaaks, Rudolf1 aJanssen, Joop, A M J L1 aWildhagen, Mark, F1 aSchröder, Fritz, H1 aPlatz, Elizabeth, A1 aPollak, Michael1 aGiovannucci, Edward1 aSchaefer, Catherine1 aQuesenberry, Charles, P1 aVogelman, Joseph, H1 aSeveri, Gianluca1 aEnglish, Dallas, R1 aGiles, Graham, G1 aStattin, Pär1 aHallmans, Göran1 aJohansson, Mattias1 aChan, June, M1 aGann, Peter1 aOliver, Steven, E1 aHolly, Jeff, M1 aDonovan, Jenny1 aMeyer, François1 aBairati, Isabelle1 aGalan, Pilar uhttps://chs-nhlbi.org/node/1055