02649nas a2200445 4500008004100000022001400041245013600055210006900191260001600260300001200276490000800288520134100296653000901637653002801646653001101674653001601685653003001701653003201731653001901763653001701782653002001799653001701819653001101836100002101847700001701868700002101885700001501906700001801921700002401939700001901963700001901982700002802001700002702029700003002056700002702086700001902113700001702132700001802149856003602167 2009 eng d a1476-625600aPrediction of incident stroke events based on retinal vessel caliber: a systematic review and individual-participant meta-analysis.0 aPrediction of incident stroke events based on retinal vessel cal c2009 Dec 01 a1323-320 v1703 a
The caliber of the retinal vessels has been shown to be associated with stroke events. However, the consistency and magnitude of association, and the changes in predicted risk independent of traditional risk factors, are unclear. To determine the association between retinal vessel caliber and the risk of stroke events, the investigators combined individual data from 20,798 people, who were free of stroke at baseline, in 6 cohort studies identified from a search of the Medline (National Library of Medicine, Bethesda, Maryland) and EMBASE (Elsevier B.V., Amsterdam, the Netherlands) databases. During follow-up of 5-12 years, 945 (4.5%) incident stroke events were recorded. Wider retinal venular caliber predicted stroke (pooled hazard ratio = 1.15, 95% confidence interval: 1.05, 1.25 per 20-micron increase in caliber), but the caliber of retinal arterioles was not associated with stroke (pooled hazard ratio = 1.00, 95% confidence interval: 0.92, 1.08). There was weak evidence of heterogeneity in the hazard ratio for retinal venular caliber, which may be attributable to differences in follow-up strategies across studies. Inclusion of retinal venular caliber in prediction models containing traditional stroke risk factors reassigned 10.1% of people at intermediate risk into different, mostly lower, risk categories.
10aAged10aFluorescein Angiography10aHumans10aMiddle Aged10aPredictive Value of Tests10aProportional Hazards Models10aRetinal Artery10aRetinal Vein10aRetinal Vessels10aRisk Factors10aStroke1 aMcGeechan, Kevin1 aLiew, Gerald1 aMacaskill, Petra1 aIrwig, Les1 aKlein, Ronald1 aKlein, Barbara, E K1 aWang, Jie, Jin1 aMitchell, Paul1 aVingerling, Johannes, R1 ade Jong, Paulus, T V M1 aWitteman, Jacqueline, C M1 aBreteler, Monique, M B1 aShaw, Jonathan1 aZimmet, Paul1 aWong, Tien, Y uhttps://chs-nhlbi.org/node/1142