02972nas a2200433 4500008004100000022001400041245013400055210006900189260001600258300001100274490000800285520171800293653001002011653000902021653002102030653001102051653001802062653001102080653002502091653000902116653001602125653002002141653003202161653002402193653002902217653002202246100002402268700002102292700002002313700002402333700002302357700002002380700001902400700002402419700001902443700002302462700001702485856003602502 2010 eng d a1524-453900aProspective study of obstructive sleep apnea and incident coronary heart disease and heart failure: the sleep heart health study.0 aProspective study of obstructive sleep apnea and incident corona c2010 Jul 27 a352-600 v1223 a
BACKGROUND: Clinic-based observational studies in men have reported that obstructive sleep apnea is associated with an increased incidence of coronary heart disease. The objective of this study was to assess the relation of obstructive sleep apnea to incident coronary heart disease and heart failure in a general community sample of adult men and women.
METHODS AND RESULTS: A total of 1927 men and 2495 women > or =40 years of age and free of coronary heart disease and heart failure at the time of baseline polysomnography were followed up for a median of 8.7 years in this prospective longitudinal epidemiological study. After adjustment for multiple risk factors, obstructive sleep apnea was a significant predictor of incident coronary heart disease (myocardial infarction, revascularization procedure, or coronary heart disease death) only in men < or =70 years of age (adjusted hazard ratio 1.10 [95% confidence interval 1.00 to 1.21] per 10-unit increase in apnea-hypopnea index [AHI]) but not in older men or in women of any age. Among men 40 to 70 years old, those with AHI > or =30 were 68% more likely to develop coronary heart disease than those with AHI <5. Obstructive sleep apnea predicted incident heart failure in men but not in women (adjusted hazard ratio 1.13 [95% confidence interval 1.02 to 1.26] per 10-unit increase in AHI). Men with AHI > or =30 were 58% more likely to develop heart failure than those with AHI <5.
CONCLUSIONS: Obstructive sleep apnea is associated with an increased risk of incident heart failure in community-dwelling middle-aged and older men; its association with incident coronary heart disease in this sample is equivocal.
10aAdult10aAged10aCoronary Disease10aFemale10aHeart Failure10aHumans10aLongitudinal Studies10aMale10aMiddle Aged10aPolysomnography10aProportional Hazards Models10aProspective Studies10aSleep Apnea, Obstructive10aSurvival Analysis1 aGottlieb, Daniel, J1 aYenokyan, Gayane1 aNewman, Anne, B1 aO'Connor, George, T1 aPunjabi, Naresh, M1 aQuan, Stuart, F1 aRedline, Susan1 aResnick, Helaine, E1 aTong, Elisa, K1 aDiener-West, Marie1 aShahar, Eyal uhttps://chs-nhlbi.org/node/1215