04709nas a2201405 4500008004100000022001400041245010700055210006900162260001300231300001200244490000700256520077800263653002601041653001801067653002001085653001701105653003801122653002201160653001801182653003401200653001101234653003101245100001801276700002601294700002401320700001401344700002901358700001701387700002101404700002101425700001501446700002101461700002201482700001901504700002301523700002201546700002401568700002001592700001601612700002301628700001801651700001801669700002701687700002501714700002501739700002501764700002201789700001901811700002001830700001901850700002001869700002001889700002001909700002601929700002001955700002501975700001902000700002102019700001802040700002902058700001902087700002002106700001602126700002002142700001902162700002002181700002102201700001602222700002302238700002002261700001802281700002202299700002402321700002202345700002302367700002302390700001702413700001902430700001802449700001702467700001702484700002202501700001902523700001702542700002002559700002002579700001902599700002402618700002102642700002102663700002002684700002202704700001702726700001902743700002302762700002602785700002002811700002402831700001802855700002002873700002302893700002102916700001902937700001902956700002202975700002202997700002303019700002303042700002303065700002203088700002403110700001903134700002203153700001703175700001703192700002203209700001803231700001803249856003603267 2010 eng d a1546-171800aGenome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.0 aGenomewide metaanalysis increases to 71 the number of confirmed c2010 Dec a1118-250 v423 a
We undertook a meta-analysis of six Crohn's disease genome-wide association studies (GWAS) comprising 6,333 affected individuals (cases) and 15,056 controls and followed up the top association signals in 15,694 cases, 14,026 controls and 414 parent-offspring trios. We identified 30 new susceptibility loci meeting genome-wide significance (P < 5 × 10⁻⁸). A series of in silico analyses highlighted particular genes within these loci and, together with manual curation, implicated functionally interesting candidate genes including SMAD3, ERAP2, IL10, IL2RA, TYK2, FUT2, DNMT3A, DENND1B, BACH2 and TAGAP. Combined with previously confirmed loci, these results identify 71 distinct loci with genome-wide significant evidence for association with Crohn's disease.
10aComputational Biology10aCrohn Disease10aGenetic Linkage10aGenetic Loci10aGenetic Predisposition to Disease10aGenetic Variation10aGenome, Human10aGenome-Wide Association Study10aHumans10aReproducibility of Results1 aFranke, Andre1 aMcGovern, Dermot, P B1 aBarrett, Jeffrey, C1 aWang, Kai1 aRadford-Smith, Graham, L1 aAhmad, Tariq1 aLees, Charlie, W1 aBalschun, Tobias1 aLee, James1 aRoberts, Rebecca1 aAnderson, Carl, A1 aBis, Joshua, C1 aBumpstead, Suzanne1 aEllinghaus, David1 aFesten, Eleonora, M1 aGeorges, Michel1 aGreen, Todd1 aHaritunians, Talin1 aJostins, Luke1 aLatiano, Anna1 aMathew, Christopher, G1 aMontgomery, Grant, W1 aPrescott, Natalie, J1 aRaychaudhuri, Soumya1 aRotter, Jerome, I1 aSchumm, Philip1 aSharma, Yashoda1 aSimms, Lisa, A1 aTaylor, Kent, D1 aWhiteman, David1 aWijmenga, Cisca1 aBaldassano, Robert, N1 aBarclay, Murray1 aBayless, Theodore, M1 aBrand, Stephan1 aBüning, Carsten1 aCohen, Albert1 aColombel, Jean-Frederick1 aCottone, Mario1 aStronati, Laura1 aDenson, Ted1 aDe Vos, Martine1 aD'Inca, Renata1 aDubinsky, Marla1 aEdwards, Cathryn1 aFlorin, Tim1 aFranchimont, Denis1 aGearry, Richard1 aGlas, Jürgen1 aVan Gossum, Andre1 aGuthery, Stephen, L1 aHalfvarson, Jonas1 aVerspaget, Hein, W1 aHugot, Jean-Pierre1 aKarban, Amir1 aLaukens, Debby1 aLawrance, Ian1 aLemann, Marc1 aLevine, Arie1 aLibioulle, Cecile1 aLouis, Edouard1 aMowat, Craig1 aNewman, William1 aPanés, Julián1 aPhillips, Anne1 aProctor, Deborah, D1 aRegueiro, Miguel1 aRussell, Richard1 aRutgeerts, Paul1 aSanderson, Jeremy1 aSans, Miquel1 aSeibold, Frank1 aSteinhart, Hillary1 aStokkers, Pieter, C F1 aTörkvist, Leif1 aKullak-Ublick, Gerd1 aWilson, David1 aWalters, Thomas1 aTargan, Stephan, R1 aBrant, Steven, R1 aRioux, John, D1 aD'Amato, Mauro1 aWeersma, Rinse, K1 aKugathasan, Subra1 aGriffiths, Anne, M1 aMansfield, John, C1 aVermeire, Severine1 aDuerr, Richard, H1 aSilverberg, Mark, S1 aSatsangi, Jack1 aSchreiber, Stefan1 aCho, Judy, H1 aAnnese, Vito1 aHakonarson, Hakon1 aDaly, Mark, J1 aParkes, Miles uhttps://chs-nhlbi.org/node/1249