03089nas a2200481 4500008004100000022001400041245004500055210004400100260001600144300000900160490000800169520183600177653000902013653001902022653001102041653000902052653002502061653001102086653002002097653000902117653002202126653001802148100002502166700002102191700001902212700002102231700002302252700002002275700002002295700002002315700001902335700003102354700002002385700002202405700002502427700002402452700001902476700002002495700001702515700002002532700001902552856003602571 2011 eng d a1538-359800aGait speed and survival in older adults.0 aGait speed and survival in older adults c2011 Jan 05 a50-80 v3053 a
CONTEXT: Survival estimates help individualize goals of care for geriatric patients, but life tables fail to account for the great variability in survival. Physical performance measures, such as gait speed, might help account for variability, allowing clinicians to make more individualized estimates.
OBJECTIVE: To evaluate the relationship between gait speed and survival.
DESIGN, SETTING, AND PARTICIPANTS: Pooled analysis of 9 cohort studies (collected between 1986 and 2000), using individual data from 34,485 community-dwelling older adults aged 65 years or older with baseline gait speed data, followed up for 6 to 21 years. Participants were a mean (SD) age of 73.5 (5.9) years; 59.6%, women; and 79.8%, white; and had a mean (SD) gait speed of 0.92 (0.27) m/s.
MAIN OUTCOME MEASURES: Survival rates and life expectancy.
RESULTS: There were 17,528 deaths; the overall 5-year survival rate was 84.8% (confidence interval [CI], 79.6%-88.8%) and 10-year survival rate was 59.7% (95% CI, 46.5%-70.6%). Gait speed was associated with survival in all studies (pooled hazard ratio per 0.1 m/s, 0.88; 95% CI, 0.87-0.90; P < .001). Survival increased across the full range of gait speeds, with significant increments per 0.1 m/s. At age 75, predicted 10-year survival across the range of gait speeds ranged from 19% to 87% in men and from 35% to 91% in women. Predicted survival based on age, sex, and gait speed was as accurate as predicted based on age, sex, use of mobility aids, and self-reported function or as age, sex, chronic conditions, smoking history, blood pressure, body mass index, and hospitalization.
CONCLUSION: In this pooled analysis of individual data from 9 selected cohorts, gait speed was associated with survival in older adults.
10aAged10aCohort Studies10aFemale10aGait10aGeriatric Assessment10aHumans10aLife Expectancy10aMale10aSurvival Analysis10aUnited States1 aStudenski, Stephanie1 aPerera, Subashan1 aPatel, Kushang1 aRosano, Caterina1 aFaulkner, Kimberly1 aInzitari, Marco1 aBrach, Jennifer1 aChandler, Julie1 aCawthon, Peggy1 aConnor, Elizabeth, Barrett1 aNevitt, Michael1 aVisser, Marjolein1 aKritchevsky, Stephen1 aBadinelli, Stefania1 aHarris, Tamara1 aNewman, Anne, B1 aCauley, Jane1 aFerrucci, Luigi1 aGuralnik, Jack uhttps://chs-nhlbi.org/node/1259