03098nas a2200421 4500008004100000022001400041245015100055210007000206260001600276300001200292490000800304520186800312653000902180653002402189653001502213653001702228653002602245653002602271653002502297653001102322653002202333653001102355653001402366653000902380653003202389653001702421653001202438100001802450700002402468700001902492700001902511700002002530700001802550700002302568700002402591700002502615856003602640 2012 eng d a1524-453900aAssociation of plasma phospholipid long-chain ω-3 fatty acids with incident atrial fibrillation in older adults: the cardiovascular health study.0 aAssociation of plasma phospholipid longchain ω3 fatty acids with c2012 Mar 06 a1084-930 v1253 a
BACKGROUND: Experimental studies suggest that long-chain n-3 polyunsaturated fatty acids (n-3 PUFAs) may reduce the risk of atrial fibrillation (AF). Prior studies evaluating fish or n-3 PUFA consumption from dietary questionnaires and incident AF have been conflicting. Circulating levels of n-3 PUFAs provide an objective measurement of exposure.
METHODS AND RESULTS: Among 3326 US men and women ≥65 years of age and free of AF or heart failure at baseline, plasma phospholipid levels of eicosapentaenoic acid, docosapentaenoic acid, and docosahexaenoic acid were measured at baseline by use of standardized methods. Incident AF (789 cases) was identified prospectively from hospital discharge records and study visit ECGs during 31 169 person-years of follow-up (1992-2006). In multivariable Cox models adjusted for other risk factors, the relative risk in the top versus lowest quartile of total n-3 PUFAs (eicosapentaenoic acid+docosapentaenoic acid+docosahexaenoic acid) levels was 0.71 (95% confidence interval, 0.57-0.89; P for trend=0.004) and of DHA levels was 0.77 (95% confidence interval, 0.62-0.96; P for trend=0.01). Eicosapentaenoic acid and docosapentaenoic acid levels were not significantly associated with incident AF. Evaluated nonparametrically, both total n-3 PUFAs and docosahexaenoic acid showed graded and linear inverse associations with incidence of AF. Adjustment for intervening events such as heart failure or myocardial infarction during follow-up did not appreciably alter results.
CONCLUSIONS: In older adults, higher circulating total long-chain n-3 PUFA and docosahexaenoic acid levels were associated with lower risk of incident AF. These results highlight the need to evaluate whether increased dietary intake of these fatty acids could be effective for the primary prevention of AF.
10aAged10aAtrial Fibrillation10aBiomarkers10aDietary Fats10aDocosahexaenoic Acids10aEicosapentaenoic Acid10aFatty Acids, Omega-310aFemale10aFollow-Up Studies10aHumans10aIncidence10aMale10aProportional Hazards Models10aRisk Factors10aSeafood1 aH Y Wu, Jason1 aLemaitre, Rozenn, N1 aKing, Irena, B1 aSong, Xiaoling1 aSacks, Frank, M1 aRimm, Eric, B1 aHeckbert, Susan, R1 aSiscovick, David, S1 aMozaffarian, Dariush uhttps://chs-nhlbi.org/node/1362