02996nas a2200433 4500008004100000022001400041245013100055210006900186260001300255300001100268490000700279520163600286653003901922653000901961653002201970653002801992653004002020653001102060653002202071653001102093653004902104653004902153653003302202653002502235653000902260653001402269653003002283653001702313100002202330700002102352700002102373700002502394700002202419700002102441700002102462700002302483700002002506856003602526 2012 eng d a1945-719700aDecline in circulating insulin-like growth factors and mortality in older adults: cardiovascular health study all-stars study.0 aDecline in circulating insulinlike growth factors and mortality c2012 Jun a1970-60 v973 a
BACKGROUND: The association between changes in IGF-I and IGF binding protein (IGFBP) levels and mortality in older adults is unknown.
STUDY DESIGN: Participants were 997 persons 77 to 100 yr old enrolled in the Cardiovascular Health Study All Stars Study. Plasma levels of IGF-I, IGFBP-1, and IGFBP-3 were assessed at two study examinations (1996-1997 and 2005-2006). Mortality was assessed between 2006 and 2010.
RESULTS: Cumulative mortality (CM) was similar among individuals who had at least 10% decreases over time in IGF-I levels (CM = 29.6%), individuals who had at least 10% increases over time in IGF-I levels (CM = 24.7%), and individuals who had IGF-I levels remaining within ±10% over time (CM = 23.5%). Adjusted for age, sex, race, diabetes, body mass index, creatinine, albumin, and C-reactive protein, decreasing IGF-I level had no significant association with overall cancer mortality or noncancer mortality. Levels of IGFBP-1 increased markedly over time by 38% (median). Individuals with the largest increases in IGFBP-1 level over time had significantly increased risk of mortality. The adjusted hazard ratio per sd of IGFBP-1 change was 1.40 for overall cancer mortality (95% confidence interval = 1.10, 1.77; P = 0.01) and 1.14 for noncancer mortality (95% confidence interval = 1.02, 1.27; P = 0.02). Changes in IGFBP-3 levels were not significantly associated with mortality.
CONCLUSION: Among older adults, decreasing IGF-I level over time does not predict subsequent all-cause mortality, whereas increasing IGFBP-1 predicts increased risk of mortality.
10aAfrican Continental Ancestry Group10aAged10aAged, 80 and over10aCardiovascular Diseases10aEuropean Continental Ancestry Group10aFemale10aFollow-Up Studies10aHumans10aInsulin-Like Growth Factor Binding Protein 110aInsulin-Like Growth Factor Binding Protein 310aInsulin-Like Growth Factor I10aLongitudinal Studies10aMale10aMortality10aPredictive Value of Tests10aRisk Factors1 aKaplan, Robert, C1 aBůzková, Petra1 aCappola, Anne, R1 aStrickler, Howard, D1 aMcGinn, Aileen, P1 aMercer, Laina, D1 aArnold, Alice, M1 aPollak, Michael, N1 aNewman, Anne, B uhttps://chs-nhlbi.org/node/1374