03041nas a2200541 4500008004100000022001400041245007600055210006900131260000900200300001100209490000600220520147100226653002201697653002101719653002101740653004001761653003201801653001701833653001101850653003601861653001801897100002001915700002401935700002201959700002101981700002102002700002102023700002202044700002502066700002202091700002102113700001902134700002002153700002802173700002102201700001502222700002202237700002202259700002302281700002002304700002502324700002202349700002102371700002802392700002202420700002102442856003602463 2012 eng d a1932-620300aMulti-ethnic analysis of lipid-associated loci: the NHLBI CARe project.0 aMultiethnic analysis of lipidassociated loci the NHLBI CARe proj c2012 ae364730 v73 a
BACKGROUND: Whereas it is well established that plasma lipid levels have substantial heritability within populations, it remains unclear how many of the genetic determinants reported in previous studies (largely performed in European American cohorts) are relevant in different ethnicities.
METHODOLOGY/PRINCIPAL FINDINGS: We tested a set of ∼50,000 polymorphisms from ∼2,000 candidate genes and genetic loci from genome-wide association studies (GWAS) for association with low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG) in 25,000 European Americans and 9,000 African Americans in the National Heart, Lung, and Blood Institute (NHLBI) Candidate Gene Association Resource (CARe). We replicated associations for a number of genes in one or both ethnicities and identified a novel lipid-associated variant in a locus harboring ICAM1. We compared the architecture of genetic loci associated with lipids in both African Americans and European Americans and found that the same genes were relevant across ethnic groups but the specific associated variants at each gene often differed.
CONCLUSIONS/SIGNIFICANCE: We identify or provide further evidence for a number of genetic determinants of plasma lipid levels through population association studies. In many loci the determinants appear to differ substantially between African Americans and European Americans.
10aAfrican Americans10aCholesterol, HDL10aCholesterol, LDL10aEuropean Continental Ancestry Group10aGenetic Association Studies10aGenetic Loci10aHumans10aPolymorphism, Single Nucleotide10aTriglycerides1 aMusunuru, Kiran1 aRomaine, Simon, P R1 aLettre, Guillaume1 aWilson, James, G1 aVolcik, Kelly, A1 aTsai, Michael, Y1 aTaylor, Herman, A1 aSchreiner, Pamela, J1 aRotter, Jerome, I1 aRich, Stephen, S1 aRedline, Susan1 aPsaty, Bruce, M1 aPapanicolaou, George, J1 aOrdovas, Jose, M1 aLiu, Kiang1 aKrauss, Ronald, M1 aGlazer, Nicole, L1 aGabriel, Stacey, B1 aFornage, Myriam1 aCupples, Adrienne, L1 aBuxbaum, Sarah, G1 aBoerwinkle, Eric1 aBallantyne, Christie, M1 aKathiresan, Sekar1 aRader, Daniel, J uhttps://chs-nhlbi.org/node/1388