01866nas a2200205 4500008004100000022001400041245016000055210006900215260000900284300001000293490000600303520117400309100002701483700002701510700002301537700002201560700002001582700002201602856003601624 2012 eng d a1948-175600aHemodynamic fluid shear stress response genes and carotid intima-media thickness: a candidate gene association analysis in the cardiovascular health study.0 aHemodynamic fluid shear stress response genes and carotid intima c2012 a174-80 v33 a

OBJECTIVE: This study examined whether carotid artery intimal-medial thickness (cIMT) is associated with genetic variations (SNPs) in a hemodynamics-responsive gene pathway.

METHODS: Subjects were Cardiovascular Health Study participants free of cardiovascular events at baseline (N=3388). Genotype was measured using Illumina 370CNV HumanHap chip. Carotid IMT was measured using ultrasound. Estimated mean differences in cIMT per additional minor allele for 366 SNPs in MAP2K5, MAPK7, MEF2A/C, and KLF2 were adjusted for sex, age, clinic, and medication use. SNP-SNP interactions were examined using logic regression for 71 tagSNPs.

RESULTS: None of the associations was significant after correction for multiple comparisons; smallest P-value=0.065 for MAP2K5 and common cIMT. The best-performing logic regression tree combined two SNPs in MAP2K5-rs745212 and rs12905175- and common cIMT; this association was not significant, corrected P-value=0.062.

CONCLUSION: There was not strong evidence of association between genetic variants in a hemodynamics-responsive gene pathway and atherosclerosis among older adults.

1 aSuchy-Dicey, Astrid, M1 aEnquobahrie, Daniel, A1 aHeckbert, Susan, R1 aRotter, Jerome, I1 aPsaty, Bruce, M1 aMcKnight, Barbara uhttps://chs-nhlbi.org/node/1394