02432nas a2200373 4500008004100000022001400041245014300055210006900198260001600267300001200283490000800295520139700303653000901700653002201709653002101731653002801752653001101780653001101791653002001802653002501822653000901847653001501856653001701871653001801888100001401906700001501920700001501935700001401950700001501964700001501979700001301994700001502007856003602022 1994 eng d a0002-926200aPrevalence of subclinical atherosclerosis and cardiovascular disease and association with risk factors in the Cardiovascular Health Study.0 aPrevalence of subclinical atherosclerosis and cardiovascular dis c1994 Jun 15 a1164-790 v1393 a
The prevalence of subclinical atherosclerosis and cardiovascular disease was evaluated among the 5,201 adults aged > or = 65 years in four communities participating in the Cardiovascular Health Study from June 1989 through May 1990. A combined index based on electrocardiogram and echocardiogram abnormalities, carotid artery wall thickness and stenosis based on carotid ultrasound, decreased ankle-brachial blood pressure, and positive response to a Rose Questionnaire for angina or intermittent claudication defined subclinical disease. The prevalence of subclinical disease was 36% in women and 38.7% in men and increased with age. Among women, low-density lipoprotein cholesterol, systolic blood pressure, blood glucose, and cigarette smoking were positively associated, and high-density lipoprotein cholesterol negatively associated, with subclinical disease. In men, systolic blood pressure, blood glucose, and cigarette smoking were independent risk factors in multiple logistic regression analyses. The risk factors for subclinical disease are, therefore, similar to those for clinical disease at younger ages, especially among women. It is possible that older individuals with subclinical disease are at very high risk of developing clinical disease and that more aggressive interventions to prevent clinical disease should be oriented to individuals with subclinical disease.
10aAged10aAged, 80 and over10aArteriosclerosis10aCardiovascular Diseases10aFemale10aHumans10aLogistic Models10aLongitudinal Studies10aMale10aPrevalence10aRisk Factors10aUnited States1 aKuller, L1 aBorhani, N1 aFurberg, C1 aGardin, J1 aManolio, T1 aO'Leary, D1 aPsaty, B1 aRobbins, J uhttps://chs-nhlbi.org/node/1434