02390nas a2200397 4500008004100000022001400041245016800055210006900223260001600292300001200308490000800320520125500328653002101583653000901604653002201613653003001635653001101665653001101676653002001687653001701707653002501724653000901749653002601758653001501784653002101799653001701820653001801837100001701855700001501872700001301887700001601900700001401916700001201930700001401942856003601956 1996 eng d a0002-926200aWhite blood cell counts in persons aged 65 years or more from the Cardiovascular Health Study. Correlations with baseline clinical and demographic characteristics.0 aWhite blood cell counts in persons aged 65 years or more from th c1996 Jun 01 a1107-150 v1433 a
A higher white blood cell (WBC) count has been shown to be a risk factor for myocardial infarction and stroke in middle-aged populations. This study evaluated the relation between baseline WBC count and other risk factors, as well as subclinical and prevalent disease, in the Cardiovascular Health Study, an epidemiologic study of coronary heart disease and stroke in 5,201 persons aged 65 years or older. Baseline data were collected over a 12-month period in 1989-1990. WBC counts were statistically significantly higher in people with prevalent and subclinical atherosclerotic cardiovascular disease than in those who were free of disease. WBC counts correlated (p < 0.01) positively with coagulation factors, measures of glucose metabolism, creatinine, smoking, and triglycerides. In contrast, WBC counts correlated negatively with high density lipoprotein cholesterol, forced expiratory volume, forced vital capacity, and height. The correlations between WBC counts and risk factors were similar in both the entire cohort and the subgroup of persons who had never smoked. The authors conclude that WBC counts in the elderly are associated with prevalent and subclinical atherosclerotic cardiovascular disease, as well as its risk factors.
10aAge Distribution10aAged10aAged, 80 and over10aCerebrovascular Disorders10aFemale10aHumans10aLeukocyte Count10aLeukocytosis10aLongitudinal Studies10aMale10aMyocardial Infarction10aPrevalence10aReference Values10aRisk Factors10aUnited States1 aBovill, E, G1 aBild, D, E1 aHeiss, G1 aKuller, L H1 aLee, M, H1 aRock, R1 aWahl, P W uhttps://chs-nhlbi.org/node/1456