02916nas a2200397 4500008004100000022001400041245017200055210006900227260001300296300001100309490000700320520176400327653000902091653002102100653001002121653002602131653002802157653002402185653001902209653002802228653002402256653001102280653001802291653001102309653003102320653000902351653001502360100001702375700001602392700001702408700001302425700001702438700001502455700001202470856003602482 1999 eng d a1079-564200aRelationships of cerebral MRI findings to ultrasonographic carotid atherosclerosis in older adults : the Cardiovascular Health Study. CHS Collaborative Research Group.0 aRelationships of cerebral MRI findings to ultrasonographic carot c1999 Feb a356-650 v193 a
Cerebral magnetic resonance imaging (MRI) has demonstrated a high prevalence of infarct-like lesions, white matter hyperintensities, and evidence of cerebral atrophy in older adults. While these findings are generally believed to be related to ischemia and atherosclerosis, their relationship to atherosclerosis in the carotid arteries remains to be explored. Study subjects were part of the multicenter Cardiovascular Health Study, a cross-sectional study of 3502 women and men >/=65 years of age undergoing cranial MRI and carotid ultrasonography. MRI infarcts were detected in 1068 participants (29.3%) and measurable carotid plaque in 2745 (75.3%). MRI infarcts, ventricular and sulcal widening, and white matter score were strongly associated with carotid intimal-medial thickness (IMT) and stenosis degree after adjustment for age and sex (all P<0. 01). Associations with plaque characteristics were less strong and less consistent; MRI infarcts were weakly associated only with surface irregularity, and ventricular size was weakly associated only with lesion density (both P<0.04). In contrast, sulcal widening was strongly related to plaque characteristics, with scores being higher in those with heterogeneous and irregular plaque (both P<0. 009). Adjustment for other risk factors, and for carotid IMT/stenosis, removed associations of MRI findings with plaque characteristics except for weak relationships remaining between MRI infarcts and surface irregularity and between sulcal score and heterogeneous plaque (both P<0.03). MRI abnormalities show strong and consistent relationships with increasing carotid IMT and stenosis degree but less strong associations with plaque characteristics, especially after adjusting for IMT and stenosis.
10aAged10aArteriosclerosis10aBrain10aCardiovascular System10aCarotid Artery Diseases10aCerebral Infarction10aCohort Studies10aCross-Sectional Studies10aEchoencephalography10aFemale10aHealth Status10aHumans10aMagnetic Resonance Imaging10aMale10aPrevalence1 aManolio, T A1 aBurke, G, L1 aO'Leary, D H1 aEvans, G1 aBeauchamp, N1 aKnepper, L1 aWard, B uhttps://chs-nhlbi.org/node/1525