03095nas a2200553 4500008004100000022001400041245013400055210006900189260001300258300001100271490000700282520158200289653001001871653001601881653000901897653002201906653001001928653001401938653002101952653001901973653001601992653002802008653001502036653001102051653001102062653001702073653002602090653000902116653001602125653001202141653001502153653003302168653001702201653001202218653001802230100002302248700001802271700002302289700002502312700002002337700002002357700001602377700002502393700002202418700002002440700002102460700002402481856003602505 2013 eng d a1873-258500aHypertension and low HDL cholesterol were associated with reduced kidney function across the age spectrum: a collaborative study.0 aHypertension and low HDL cholesterol were associated with reduce c2013 Mar a106-110 v233 a
PURPOSE: To determine if the associations among established risk factors and reduced kidney function vary by age.
METHODS: We pooled cross-sectional data from 14,788 nondiabetics aged 40 to 100 years in 4 studies: Cardiovascular Health Study, Health, Aging, and Body Composition Study, Multi-Ethnic Study of Atherosclerosis, and Prevention of Renal and Vascular End-Stage Disease cohort.
RESULTS: Hypertension and low high-density lipoprotein (HDL) cholesterol were associated with reduced cystatin C-based estimated glomerular filtration rate (eGFR) across the age spectrum. In adjusted analyses, hypertension was associated with a 2.3 (95% confidence interval [CI], 0.1, 4.4), 5.1 (95% CI, 4.1, 6.1), and 6.9 (95% CI, 3.0, 10.4) mL/min/1.73 m(2) lower eGFR in participants 40 to 59, 60 to 79, and at least 80 years, respectively (P for interaction < .001). The association of low HDL cholesterol with reduced kidney function was also greater in the older age groups: 4.9 (95% CI, 3.5, 6.3), 7.1 (95% CI, 6.0, 8.3), 8.9 (95% CI, 5.4, 11.9) mL/min/1.73 m(2) (P for interaction < .001). Smoking and obesity were associated with reduced kidney function in participants under 80 years. All estimates of the potential population impact of the risk factors were modest.
CONCLUSIONS: Hypertension, obesity, smoking, and low HDL cholesterol are modestly associated with reduced kidney function in nondiabetics. The associations of hypertension and HDL cholesterol with reduced kidney function seem to be stronger in older adults.
10aAdult10aAge Factors10aAged10aAged, 80 and over10aAging10aCausality10aCholesterol, LDL10aCohort Studies10aComorbidity10aCross-Sectional Studies10aCystatin C10aFemale10aHumans10aHypertension10aKidney Function Tests10aMale10aNetherlands10aObesity10aPrevalence10aRenal Insufficiency, Chronic10aRisk Factors10aSmoking10aUnited States1 aOdden, Michelle, C1 aTager, Ira, B1 aGansevoort, Ron, T1 aBakker, Stephan, J L1 aFried, Linda, F1 aNewman, Anne, B1 aKatz, Ronit1 aSatterfield, Suzanne1 aHarris, Tamara, B1 aSarnak, Mark, J1 aSiscovick, David1 aShlipak, Michael, G uhttps://chs-nhlbi.org/node/5854