02448nas a2200493 4500008004100000022001400041245018100055210006900236260001700305300001000322490000700332520103400339653002101373653001601394653000901410653001001419653002401429653003401453653002801487653002701515653001101542653001101553653001601564653001801580653003101598653000901629653002601638653001701664653003001681653002101711653001601732653001201748653001101760100002001771700001701791700001701808700001601825700001301841700001901854700001501873700001801888700001301906856003501919 2000 eng d a0251-535000aClinical correlates of ventricular and sulcal size on cranial magnetic resonance imaging of 3,301 elderly people. The Cardiovascular Health Study. Collaborative Research Group.0 aClinical correlates of ventricular and sulcal size on cranial ma c2000 Jan-Feb a30-420 v193 a
To identify potential risk factors for and clinical manifestations of ventricular and sulcal enlargement on cranial magnetic resonance imaging (MRI), 3,301 community-dwelling people 65 years or older without a history of stroke or transient ischemic attack underwent extensive standardized evaluations and MRI. In the multivariate model, increased age and white matter grade on MRI were the dominant risk factors for ventricular and sulcal grade. For ventricular grade, other than race, for which non-Blacks had higher grades, models for men and women shared no other factors. For sulcal grades, models for men and women shared variables reflecting cigarette smoking and diabetes. Clinical features were correlated more strongly with ventricular than sulcal grade and more strongly for women than men. Significant age-adjusted correlations between ventricular grade and the Digit-Symbol Substitution Test were found for men and women. Prospective studies will be needed to extend findings of this cross-sectional analysis.
10aAge Distribution10aAge Factors10aAged10aAging10aCerebral Ventricles10aContinental Population Groups10aCross-Sectional Studies10aDiabetes Complications10aFemale10aHumans10aHypertrophy10aLinear Models10aMagnetic Resonance Imaging10aMale10aMultivariate Analysis10aRisk Factors10aSeverity of Illness Index10aSex Distribution10aSex Factors10aSmoking10aStroke1 aLongstreth, W T1 aArnold, A, M1 aManolio, T A1 aBurke, G, L1 aBryan, N1 aJungreis, C, A1 aO'Leary, D1 aEnright, P, L1 aFried, L uhttps://chs-nhlbi.org/node/608