02519nas a2200445 4500008004100000022001400041245010200055210006900157260001300226300001100239490000800250520134300258653001001601653000901611653002201620653001201642653002801654653001101682653001101693653002901704653000901733653001601742653002301758653001101781653001901792653002001811653001701831653002601848100001501874700001601889700001801905700001501923700001901938700001901957700001801976700001601994700001602010700001202026856003502038 2000 eng d a1073-449X00aEffects of varying approaches for identifying respiratory disturbances on sleep apnea assessment.0 aEffects of varying approaches for identifying respiratory distur c2000 Feb a369-740 v1613 a
Varying approaches to measuring the respiratory disturbance index (RDI) may lead to discrepant estimates of the severity of sleep-disordered breathing (SDB). In this study, we assessed the impact of varying the use of corroborative data (presence and degree of desaturation and/or arousal) to identify hypopneas and apneas. The relationships among 10 RDIs defined by various definitions of apneas and hypopneas were assessed in 5,046 participants in the Sleep Heart Health Study (SHHS) who underwent overnight unattended 12-channel polysomnography (PSG). The magnitude of the median RDI varied 10-fold (i.e., 29.3 when the RDI was based on events identified on the basis of flow or volume amplitude criteria alone to 2.0 for an RDI that required an associated 5% desaturation with events). The correlation between RDIs based on different definitions ranged from 0.99 to 0.68. The highest correlations were among RDIs that required apneas and hypopneas to be associated with some level of desaturation. Lower correlations were observed between RDIs that required desaturation as compared with RDIs defined on the basis of amplitude criteria alone or associated arousal. These data suggest that different approaches for measuring the RDI may contribute to substantial variability in identification and classification of the disorder.
10aAdult10aAged10aAged, 80 and over10aArousal10aDiagnosis, Differential10aFemale10aHumans10aLung Volume Measurements10aMale10aMiddle Aged10aObserver Variation10aOxygen10aOxyhemoglobins10aPolysomnography10aRisk Factors10aSleep Apnea Syndromes1 aRedline, S1 aKapur, V, K1 aSanders, M, H1 aQuan, S, F1 aGottlieb, D, J1 aRapoport, D, M1 aBonekat, W, H1 aSmith, P, L1 aKiley, J, P1 aIber, C uhttps://chs-nhlbi.org/node/609