03288nas a2200529 4500008004100000022001400041245016400055210006900219260001600288300001100304490000800315520171900323653001602042653001702058653000902075653001502084653002802099653003002127653003802157653001102195653002202206653001802228653001102246653001402257653000902271653001402280653002402294653001502318653003002333653001802363653003102381100002002412700002002432700002102452700002002473700001802493700002402511700001902535700002102554700002402575700002202599700002702621700002402648700003002672700002002702856003602722 2014 eng d a1879-191300aRelations of plasma total and high-molecular-weight adiponectin to new-onset heart failure in adults ≥65 years of age (from the Cardiovascular Health study).0 aRelations of plasma total and highmolecularweight adiponectin to c2014 Jan 15 a328-340 v1133 a
Adiponectin exhibits cardioprotective properties in experimental studies, but elevated levels have been linked to increased mortality in older adults and patients with chronic heart failure (HF). The adipokine's association with new-onset HF remains less well defined. The aim of this study was to investigate the associations of total and high-molecular weight (HMW) adiponectin with incident HF (n = 780) and, in a subset, echocardiographic parameters in a community-based cohort of adults aged ≥65 years. Total and HMW adiponectin were measured in 3,228 subjects without prevalent HF, atrial fibrillation or CVD. The relations of total and HMW adiponectin with HF were nonlinear, with significant associations observed only for concentrations greater than the median (12.4 and 6.2 mg/L, respectively). After adjustment for potential confounders, the hazard ratios per SD increment in total adiponectin were 0.93 (95% confidence interval 0.72 to 1.21) for concentrations less than the median and 1.25 (95% confidence interval 1.14 to 1.38) higher than the median. There was a suggestion of effect modification by body mass index, whereby the association appeared strongest in participants with lower body mass indexes. Consistent with the HF findings, higher adiponectin tended to be associated with left ventricular systolic dysfunction and left atrial enlargement. Results were similar for HMW adiponectin. In conclusion, total and HMW adiponectin showed comparable relations with incident HF in this older cohort, with a threshold effect of increasing risk occurring at their median concentrations. High levels of adiponectin may mark or mediate age-related processes that lead to HF in older adults.
10aAdiponectin10aAge of Onset10aAged10aBiomarkers10aCross-Sectional Studies10aEchocardiography, Doppler10aEnzyme-Linked Immunosorbent Assay10aFemale10aFollow-Up Studies10aHeart Failure10aHumans10aIncidence10aMale10aPrognosis10aProspective Studies10aRecurrence10aSeverity of Illness Index10aUnited States10aVentricular Function, Left1 aKaras, Maria, G1 aBenkeser, David1 aArnold, Alice, M1 aBartz, Traci, M1 aDjoussé, Luc1 aMukamal, Kenneth, J1 aIx, Joachim, H1 aZieman, Susan, J1 aSiscovick, David, S1 aTracy, Russell, P1 aMantzoros, Christos, S1 aGottdiener, John, S1 adeFilippi, Christopher, R1 aKizer, Jorge, R uhttps://chs-nhlbi.org/node/6137