02718nas a2200337 4500008004100000022001400041245011700055210006900172260001300241300001100254490000700265520176300272653000902035653002202044653002602066653002102092653002002113653001902133653001102152653001102163653001902174653000902193653001802202653001602220100002302236700002102259700002102280700002202301700002102323856003602344 2014 eng d a1945-719700aSubclinical hypothyroidism, weight change, and body composition in the elderly: the Cardiovascular Health Study.0 aSubclinical hypothyroidism weight change and body composition in c2014 Apr a1220-60 v993 a

BACKGROUND: Subclinical hypothyroidism is common in the elderly, yet its relationship with weight and body composition is unclear.

OBJECTIVE: We examined the relationship between subclinical hypothyroidism and weight change and body composition in older adults.

METHODS: A total of 427 subclinically hypothyroid and 2864 euthyroid U.S. individuals ≥65 years old enrolled in the Cardiovascular Health Study and not taking thyroid preparations were included. Analyses of 6-year weight change were performed, compared by thyroid status. A cross-sectional analysis of thyroid status and body composition was performed in a subset of 1276 participants who had dual-energy x-ray absorptiometry scans. Models were risk factor-adjusted and stratified by sex.

RESULTS: Overall, participants lost weight during follow-up (-0.38 kg/y in men, -0.37 kg/y in women). Subclinical hypothyroidism, when assessed at a single time point or persisting over 2 years, was not associated with a difference in weight change compared with euthyroidism. Subclinical hypothyroidism was also not associated with differences in lean mass, fat mass, or percent fat compared with euthyroidism. A TSH level 1 mU/L higher within the euthyroid or subclinical hypothyroid range was associated with a 0.51-kg higher baseline weight in women only (P < .001) but not with weight change in either sex. A 1 ng/dL higher free T4 level was associated with lower baseline weight and 0.32 kg/y greater weight loss in women only (P = .003). Baseline weight and weight change did not differ by T3 levels.

CONCLUSIONS: Our data do not support a clinically significant impact of subclinical hypothyroidism on weight status in the elderly.

10aAged10aAged, 80 and over10aAsymptomatic Diseases10aBody Composition10aBody Mass Index10aCohort Studies10aFemale10aHumans10aHypothyroidism10aMale10aThyroid Gland10aWeight Loss1 aGarin, Margaret, C1 aArnold, Alice, M1 aLee, Jennifer, S1 aTracy, Russell, P1 aCappola, Anne, R uhttps://chs-nhlbi.org/node/6213