02445nas a2200349 4500008004100000022001400041245010300055210006900158260001600227300001100243490000700254520148900261653000901750653002201759653002901781653001101810653001101821653002501832653000901857653003001866653001101896653002201907653001801929100002001947700001501967700001901982700001502001700001502016700001202031700001702043856003502060 2001 eng d a0028-387800aFrequency and predictors of stroke death in 5,888 participants in the Cardiovascular Health Study.0 aFrequency and predictors of stroke death in 5888 participants in c2001 Feb 13 a368-750 v563 a
BACKGROUND: Few population-based studies have examined in detail issues of stroke-related deaths in elderly people.
METHODS: Participants in the Cardiovascular Health Study (CHS) are 65 years of age or older, have had extensive baseline evaluations, and have been followed-up for fatal and nonfatal cardiovascular and cerebrovascular disease outcomes. Investigators adjudicated these outcomes and classified strokes by types and subtypes.
RESULTS: Over 7 years, 1,310 (22.2%) of 5,888 participants died, and 455 (7.7%) experienced incident stroke. For the 5,888, stroke mortality was 3.2 per 1,000 person-years. For the 455, it was 36.1 per 1,000 person-years, with the most lethal type being hemorrhagic and the ischemic subtype being cardioembolic. After controlling for age and stroke type, the only other independent predictor of death after any stroke was poor performance on a timed walk measured before the incident stroke. Considering only ischemic stroke, the independent predictors of death were African American race and poor performance on timed walk.
CONCLUSION: In CHS, death attributable to stroke is common. As in other studies, the most lethal stroke type was hemorrhagic, and ischemic stroke subtype, cardioembolic. Slow walking, possibly a measure of frailty, was associated with an increased risk of death of stroke. Finally, African Americans faced a greater risk of death than others after an ischemic stroke.
10aAged10aAged, 80 and over10aClinical Trials as Topic10aFemale10aHumans10aLongitudinal Studies10aMale10aPredictive Value of Tests10aStroke10aSurvival Analysis10aUnited States1 aLongstreth, W T1 aBernick, C1 aFitzpatrick, A1 aCushman, M1 aKnepper, L1 aLima, J1 aFurberg, C D uhttps://chs-nhlbi.org/node/629