02403nas a2200361 4500008004100000022001400041245009100055210006900146260001700215300001000232490000700242520142400249653000901673653001001682653000901692653002101701653002101722653001101743653003101754653001101785653001101796653001101807653000901818653002401827653003101851100002601882700001601908700002101924700002001945700002101965700001901986856003602005 2014 eng d a1873-124400aDietary protein intake and change in estimated GFR in the Cardiovascular Health Study.0 aDietary protein intake and change in estimated GFR in the Cardio c2014 Jul-Aug a794-90 v303 a
OBJECTIVE: With aging, kidney function declines, as evidenced by reduced glomerular filtration rate. It is controversial whether or not high protein intake accelerates this decline. The aim of this study was to determine whether high protein intake was associated with declines in kidney function among older patients.
METHODS: We examined whether dietary protein is associated with change in kidney function (mean follow-up 6.4 y [SD = 1.4, range = 2.5-7.9] in the Cardiovascular Health Study (N = 3623). We estimated protein intake using a food frequency questionnaire and estimated glomerular filtration rate from cystatin C. Associations between protein intake and kidney function were determined by linear and logistic regression models.
RESULTS: Average protein intake was 19% of energy intake (SD = 5%). Twenty-seven percent (n = 963) of study participants had rapid decline in kidney function, as defined by (ΔeGFRcysC > 3 mL•min•1.73 m(2)). Protein intake (characterized as g/d and % energy/d), was not associated with change in estimated glomerular filtration rate (P > 0.05 for all comparisons). There were also no significant associations when protein intake was separated by source (animal and vegetable).
CONCLUSION: These data suggest that higher protein intake does not have a major effect on kidney function decline among elderly men and women.
10aAged10aAging10aDiet10aDietary Proteins10aFeeding Behavior10aFemale10aGlomerular Filtration Rate10aHealth10aHumans10aKidney10aMale10aRegression Analysis10aSurveys and Questionnaires1 aBeasley, Jeannette, M1 aKatz, Ronit1 aShlipak, Michael1 aRifkin, Dena, E1 aSiscovick, David1 aKaplan, Robert uhttps://chs-nhlbi.org/node/6546