03000nas a2200397 4500008004100000022001400041245010600055210006900161260001300230300001000243490000700253520190400260653000902164653002202173653001002195653001002205653001102215653001502226653001102241653001702252653002302269653002502292653000902317653001902326653001702345653002102362100002202383700002402405700002702429700002402456700001902480700002402499700002302523700002102546856003502567 2002 eng d a0895-706100aCorrelates of aortic stiffness in elderly individuals: a subgroup of the Cardiovascular Health Study.0 aCorrelates of aortic stiffness in elderly individuals a subgroup c2002 Jan a16-230 v153 a
BACKGROUND: Arterial stiffness has been associated with aging, hypertension, and diabetes; however, little data has been published examining risk factors associated with arterial stiffness in elderly individuals.
METHODS: Longitudinal associations were made between aortic stiffness and risk factors measured approximately 4 years earlier. Aortic pulse wave velocity (PWV), an established index of arterial stiffness, was measured in 356 participants (53.4% women, 25.3% African American), aged 70 to 96 years, from the Pittsburgh site of the Cardiovascular Health Study during 1996 to 1998.
RESULTS: Mean aortic pulse wave velocity (850 cm/sec, range 365 to 1863) did not differ by ethnicity or sex. Increased aortic stiffness was positively associated with higher systolic blood pressure (SBP), age, fasting and 2-h postload glucose, fasting and 2-h insulin, triglycerides, waist circumference, body mass index, truncal fat, decreased physical activity, heart rate, and common carotid artery wall thickness (P < .05). After controlling for age and SBP, the strongest predictors of aortic stiffness in men were heart rate (P = .001) and 2-h glucose (P = .063). In women, PWV was positively associated with heart rate (P = .018), use of antihypertensive medication (P = .035), waist circumference (P = .030), and triglycerides (P = .081), and was negatively associated with physical activity (P = .111). Results were similar when the analysis was repeated in nondiabetic individuals and in those free of clinical or subclinical cardiovascular disease in 1992 to 1993.
CONCLUSIONS: In these elderly participants, aortic stiffness was positively associated with risk factors associated with the insulin resistance syndrome, increased common carotid intima-media thickness, heart rate, and decreased physical activity measured several years earlier.
10aAged10aAged, 80 and over10aAging10aAorta10aFemale10aHeart Rate10aHumans10aHypertension10aInsulin Resistance10aLongitudinal Studies10aMale10aPulsatile Flow10aRisk Factors10aSex Distribution1 aMackey, Rachel, H1 aSutton-Tyrrell, Kim1 aVaitkevicius, Peter, V1 aSakkinen, Pamela, A1 aLyles, Mary, F1 aSpurgeon, Harold, A1 aLakatta, Edward, G1 aKuller, Lewis, H uhttps://chs-nhlbi.org/node/677