02191nas a2200205 4500008004100000022001400041245008400055210006900139260001300208300001100221490000700232520158100239100002301820700002201843700001801865700002301883700002201906700002101928856003601949 2016 eng d a1941-722500aOrthostatic Hypotension and Risk of Venous Thromboembolism in 2 Cohort Studies.0 aOrthostatic Hypotension and Risk of Venous Thromboembolism in 2  c2016 May a634-400 v293 a

BACKGROUND: Although venous stasis is a risk factor for venous thromboembolism (VTE) and orthostatic hypotension (OH) can cause venous stasis, to our knowledge no study has examined the relationship between OH and VTE risk. We sought to quantify the association between OH and VTE (deep vein thrombosis or pulmonary embolism) using data from 2 large, prospective cohort studies: the Cardiovascular Health Study (CHS) and the Atherosclerosis Risk in Communities (ARIC) Study. We hypothesized that OH was positively associated with incident VTE.

METHODS: We measured OH-defined as a drop in systolic blood pressure (SBP) of at least 20 mm Hg or diastolic blood pressure (DBP) of at least 10 mm Hg within 3 minutes of standing-in participants aged 45-64 years in ARIC (n = 12,480) and ≥65 years in CHS (n = 5,027) at baseline visits (1987-1989 in ARIC; 1989-1990 and 1992-1993 in CHS), and followed participants for incident VTE (n = 568 in ARIC through 2011 and n = 148 in CHS through 2001). We calculated adjusted hazard ratios (HRs) and their 95% confidence intervals (CIs) for incident VTE in relation to OH status.

RESULTS: In CHS, there was a positive association between OH status and incident VTE (HR for VTE = 1.74 (95% CI: 1.20-2.51)). In contrast, there was no association between OH and VTE in the ARIC study (HR for VTE = 0.97 (95% CI: 0.70-1.33)).

CONCLUSIONS: Community-dwelling older adults with OH had a moderately increased risk of VTE. These results were not seen in a population-based middle-aged cohort.

1 aBell, Elizabeth, J1 aAgarwal, Sunil, K1 aCushman, Mary1 aHeckbert, Susan, R1 aLutsey, Pamela, L1 aFolsom, Aaron, R uhttps://chs-nhlbi.org/node/6807