02711nas a2200505 4500008004100000022001400041245016300055210006900218260001300287300001100300490000700311520127900318653002801597653000901625653002201634653001201656653002001668653001901688653002801707653002501735653001601760653002201776653001101798653003801809653001101847653002001858653001701878653000901895653001301904653002601917653001201943653003001955653001601985653001702001653001202018653001102030653001202041100002002053700002002073700001902093700001802112700001802130700002202148856003502170 2002 eng d a0340-624500aNo association of plasma prothrombin concentration or the G20210A mutation with incident cardiovascular disease: results from the Cardiovascular Health Study.0 aNo association of plasma prothrombin concentration or the G20210 c2002 Apr a614-210 v873 a
Prothrombin is a key factor in blood clotting, a process intimately involved in thrombotic disease. We assessed prothrombin levels and G20210A genotype in a case-control study within the Cardiovascular Health Study. Cases included angina, myocardial infarction, stroke, and the presence of MRI-detectable infarcts (n approximately 250 each). Population-based controls free of clinical cardiovascular disease (CVD) (n approximately 500) and a subset free of clinical and subclinical CVD (n approximately 250) were used for comparison. The 20210 A allele, frequency 2.9%, was associated with higher mean prothrombin levels: 166.3 vs. 139.5 microg/ml (P <0.001). Significant correlates of prothrombin included gender, plasma lipids, other vitamin K-dependent proteins, and inflammatory markers, but not race, smoking, hypertension, diabetes, measures of subclinical CVD, or markers of procoagulant activity. Compared to controls, neither genotype nor prothrombin level was associated with any CVD case group. We conclude that, in the elderly, neither prothrombin level nor 20210 genotype were associated with either CVD risk factors or events. This is consistent with the lack of association of prothrombin levels with measures of underlying CVD or procoagulant markers.
10a3' Untranslated Regions10aAged10aAged, 80 and over10aAlleles10aAngina Pectoris10aBlood Proteins10aCardiovascular Diseases10aCase-Control Studies10aComorbidity10aDiabetes Mellitus10aFemale10aGenetic Predisposition to Disease10aHumans10aHyperlipidemias10aHypertension10aMale10aMutation10aMyocardial Infarction10aObesity10aPromoter Regions, Genetic10aProthrombin10aRisk Factors10aSmoking10aStroke10aVermont1 aSmiles, Adam, M1 aJenny, Nancy, S1 aTang, Zhonghua1 aArnold, Alice1 aCushman, Mary1 aTracy, Russell, P uhttps://chs-nhlbi.org/node/690