02003nas a2200217 4500008004100000022001400041245008900055210006900144260001300213300000900226490000800235520136200243100002301605700002101628700002201649700002201671700001901693700001801712700001901730856003601749 2016 eng d a1872-822700aDiabetes mellitus and venous thromboembolism: A systematic review and meta-analysis.0 aDiabetes mellitus and venous thromboembolism A systematic review c2016 Jan a10-80 v1113 a

UNLABELLED: Diabetes mellitus (DM) may be a risk factor for venous thromboembolism (VTE) but results are inconsistent.

AIM: We conducted a systematic review and meta-analysis of epidemiologic studies to quantify the association between DM and VTE.

METHODS AND RESULTS: We included studies identified in PubMed, Web of Science, and CINAHL through 07/31/2014. We identified 19 studies that met our selection criteria. We pooled RRs using a random-effects model: the pooled RR for the association of DM with VTE was 1.10 (95% CI: 0.94-1.29). Between-study heterogeneity was explored with a forest plot, funnel plot, meta-regression, and a stratified analysis. Between-study heterogeneity was observed and not explained by study design, method of DM assessment, or degree of adjustment for confounding. Sensitivity analyses omitted one study at a time to assess the influence of any single study on the pooled estimate. These analyses indicated that one large study was highly influential; when this study was excluded, the pooled estimate increased and just reached statistical significance: 1.16 (95% CI: 1.01-1.34).

CONCLUSIONS: This meta-analysis suggests either no association or a modest positive one between DM and VTE in the general population. DM is unlikely to play a major role in VTE development.

1 aBell, Elizabeth, J1 aFolsom, Aaron, R1 aLutsey, Pamela, L1 aSelvin, Elizabeth1 aZakai, Neil, A1 aCushman, Mary1 aAlonso, Alvaro uhttps://chs-nhlbi.org/node/6905