02775nas a2200409 4500008004100000022001400041245010100055210006900156260001300225300001200238490000700250520162100257653000901878653002201887653004201909653001001951653003001961653001901991653001602010653001502026653002402041653001102065653001902076653001102095653001402106653002002120653003102140653000902171653002902180653001502209653001802224100002302242700002602265700001702291700002202308856003502330 2002 eng d a1524-462800aCerebrovascular disease and evolution of depressive symptoms in the cardiovascular health study.0 aCerebrovascular disease and evolution of depressive symptoms in c2002 Jun a1636-440 v333 a
BACKGROUND AND PURPOSE: Previous studies have reported an association between cerebrovascular disease and depressive symptoms. The Cardiovascular Health Study (CHS) provides an opportunity to examine the relationship between vascular brain pathology seen on neuroimaging and changes in depressive symptoms.
METHODS: The sample included 3236 CHS participants who had an MRI brain scan. Demographic variables, medical history, functional status, and apolipoprotein E genotype were obtained at baseline. Annual scores on a modified version of the Centers for Epidemiologic Studies Depression (CES-D) scale were obtained initially and up to 7 years subsequently.
RESULTS: After controlling for important covariates, occurrence of depressive symptoms (defined as modified CES-D score of >7) was associated with small lesions in the basal ganglia, large cortical white-matter lesions, and severe subcortical white-matter grade. Neuroimaging variables did not predict incident depression among those who were nondepressive at the time of MRI. Persistence of depressive symptoms across 2 consecutive time points was associated with small basal ganglia lesions and large cerebral cortical white-matter lesions. Worsening of depression (increase in CES-D score of > or =5) was associated with subcortical white-matter lesions.
CONCLUSIONS: These findings suggest that cerebrovascular disease at baseline is related to depression symptoms over time. Further studies are needed to investigate the differential effects of subcortical white- versus gray-matter lesions on mood.
10aAged10aAged, 80 and over10aBasal Ganglia Cerebrovascular Disease10aBrain10aCerebrovascular Disorders10aCohort Studies10aComorbidity10aDepression10aDisease Progression10aFemale10aHealth Surveys10aHumans10aIncidence10aLogistic Models10aMagnetic Resonance Imaging10aMale10aNeuropsychological Tests10aOdds Ratio10aUnited States1 aSteffens, David, C1 aKrishnan, Ranga, Rama1 aCrump, Casey1 aBurke, Gregory, L uhttps://chs-nhlbi.org/node/692