02884nas a2200277   4500008004100000022001400041245005400055210005300109260000900162300001300171490000700184520211400191100002702305700001802332700002302350700001802373700002202391700002202413700002302435700002502458700002102483700002202504700002002526700002402546856003602570       2016                        eng d  a1932-620300aVitamin D and Risk of Neuroimaging Abnormalities.0 aVitamin D and Risk of Neuroimaging Abnormalities  c2016  ae01548960 v113 a<p>Vitamin D deficiency has been linked with an increased risk of incident all-cause dementia and Alzheimer's disease. The aim of the current study was to explore the potential mechanisms underlying these associations by determining whether low vitamin D concentrations are associated with the development of incident cerebrovascular and neurodegenerative neuroimaging abnormalities. The population consisted of 1,658 participants aged ≥65 years from the US-based Cardiovascular Health Study who were free from prevalent cardiovascular disease, stroke and dementia at baseline in 1992-93. Serum 25-hydroxyvitamin D (25(OH)D) concentrations were determined by liquid chromatography-tandem mass spectrometry from blood samples collected at baseline. The first MRI scan was conducted between 1991-1994 and the second MRI scan was conducted between 1997-1999. Change in white matter grade, ventricular grade and presence of infarcts between MRI scan one and two were used to define neuroimaging abnormalities. During a mean follow-up of 5.0 years, serum 25(OH)D status was not significantly associated with the development of any neuroimaging abnormalities. Using logistic regression models, the multivariate adjusted odds ratios (95% confidence interval) for worsening white matter grade in participants who were severely 25(OH)D deficient (<25 nmol/L) and deficient (≥25-50 nmol/L) were 0.76 (0.35-1.66) and 1.09 (0.76-1.55) compared to participants with sufficient concentrations (≥50 nmol/L). The multivariate adjusted odds ratios for ventricular grade in participants who were severely 25(OH)D deficient and deficient were 0.49 (0.20-1.19) and 1.12 (0.79-1.59) compared to those sufficient. The multivariate adjusted odds ratios for incident infarcts in participants who were severely 25(OH)D deficient and deficient were 1.95 (0.84-4.54) and 0.73 (0.47-1.95) compared to those sufficient. Overall, serum vitamin D concentrations could not be shown to be associated with the development of cerebrovascular or neurodegenerative neuroimaging abnormalities in Cardiovascular Health Study participants.</p>1 aLittlejohns, Thomas, J1 aKos, Katarina1 aHenley, William, E1 aLang, Iain, A1 aAnnweiler, Cedric1 aBeauchet, Olivier1 aChaves, Paulo, H M1 aKestenbaum, Bryan, R1 aKuller, Lewis, H1 aLanga, Kenneth, M1 aLopez, Oscar, L1 aLlewellyn, David, J  uhttps://chs-nhlbi.org/node/7126