01869nas a2200205 4500008004100000022001400041245014500055210006900200260001600269300002000285520116300305100002501468700002501493700001701518700002201535700002701557700002301584700002001607856003601627 2017 eng d a1552-688700aRole of Late-Life Depression in the Association of Subclinical Cardiovascular Disease With All-Cause Mortality: Cardiovascular Health Study.0 aRole of LateLife Depression in the Association of Subclinical Ca c2017 Nov 01 a8982643177449213 a

OBJECTIVES: To evaluate whether late-life depression mediates the association of subclinical cardiovascular disease (CVD) with all-cause mortality.

METHOD: Using data from 3,473 Cardiovascular Health Study participants, the Cox proportional hazards model was used to examine the direct and indirect (via late-life depression) effects of the association between baseline subclinical CVD and all-cause mortality with weights derived from multivariable logistic regression of late-life depression on subclinical CVD.

RESULTS: Subclinical CVD led to a higher risk of all-cause mortality (hazard ratio [HR] = 1.51, 95% confidence interval, [CI] = [1.42, 1.94]). Total effect of subclinical CVD on all-cause mortality was decomposed into direct (HR = 1.41, 95% CI = [1.37, 1.58]) and indirect (HR = 1.07, 95% CI = [1.01, 1.23]) effects; 16.3% of the total effect of subclinical CVD on all-cause mortality was mediated by late-life depression.

DISCUSSION: Late-life depression accounts for little, if any, of the association between subclinical CVD, a risk factor of all-cause mortality, and all-cause mortality.

1 aArmstrong, Nicole, M1 aCarlson, Michelle, C1 aXue, Qian-Li1 aSchrack, Jennifer1 aCarnethon, Mercedes, R1 aChaves, Paulo, H M1 aGross, Alden, L uhttps://chs-nhlbi.org/node/7545