03000nas a2200517 4500008004100000022001400041245014300055210006900198260001600267300001400283490000800297520149600305653000901801653002201810653002801832653003101860653002001891653002801911653001901939653000901958653001301967653001101980653002401991653002202015653001102037653001402048653002502062653000902087653001402096653003302110653002402143653001802167100002202185700002202207700002002229700002202249700001902271700002302290700002102313700002202334700002802356700002202384700002002406700002002426856003602446 2017 eng d a1476-625600aConcordance With Prevention Guidelines and Subsequent Cancer, Cardiovascular Disease, and Mortality: A Longitudinal Study of Older Adults.0 aConcordance With Prevention Guidelines and Subsequent Cancer Car c2017 Nov 15 a1168-11790 v1863 a
Reports on the associations between multiple clinical and behavioral health indicators and major health outcomes among older adults are scarce. We prospectively examined concordance with guidelines from the American Cancer Society and American Heart Association for disease prevention in relation to cancer, cardiovascular disease (CVD), and mortality among Cardiovascular Health Study enrollees aged 65-98 years who, at baseline assessment in 1989-1996 (n = 3,491), were free of CVD and cancer. Total and cause-specific mortality, as well as incidence of cancer and CVD, were lower with higher guideline concordance. Independent of body mass index, blood pressure, total cholesterol, and fasting plasma glucose, better health behaviors (diet, physical activity, and alcohol consumption) were associated with lower mortality (2-sided P < 0.0001). Among individuals with ideal levels for 3-4 of these 4 cardiometabolic biomarkers, those with poor concordance with health behavior recommendations had higher mortality compared with those who had the highest concordance with these behavioral recommendations (adjusted mortality hazard ratio = 1.82, 95% confidence interval: 1.25, 2.67). Older adults who are concordant with recommendations for cancer and CVD prevention have reduced rates of chronic disease and mortality. Interventions to achieve and maintain healthy lifestyle behaviors may offer benefits both in the presence and absence of adverse traditional clinical risk factors.
10aAged10aAged, 80 and over10aAmerican Cancer Society10aAmerican Heart Association10aBody Mass Index10aCardiovascular Diseases10aCause of Death10aDiet10aExercise10aFemale10aGuideline Adherence10aHealthy Lifestyle10aHumans10aIncidence10aLongitudinal Studies10aMale10aNeoplasms10aPractice Guidelines as Topic10aProspective Studies10aUnited States1 aGreenlee, Heather1 aStrizich, Garrett1 aLovasi, Gina, S1 aKaplan, Robert, C1 aBiggs, Mary, L1 aLi, Christopher, I1 aRichardson, John1 aBurke, Gregory, L1 aFitzpatrick, Annette, L1 aFretts, Amanda, M1 aPsaty, Bruce, M1 aFried, Linda, P uhttps://chs-nhlbi.org/node/7563