02879nas a2200337 4500008004100000022001400041245016400055210006900219260001600288300001100304490000700315520187000322653000902192653002802201653002102229653001102250653001102261653001602272653001402288653000902302653003002311653001502341653002402356653002002380100002002400700002102420700002102441700002102462700002302483856003502506 2004 eng d a0735-109700aPrevalence of specific variant carotid geometric patterns and incidence of cardiovascular events in older persons. The Cardiovascular Health Study (CHS E-131).0 aPrevalence of specific variant carotid geometric patterns and in c2004 Jan 21 a187-930 v433 a

OBJECTIVES: We hypothesized that variant geometric patterns of the common carotid artery (CCA) predict the incidence of cardiovascular disease (CVD), after accounting for CCA intima-medial thickness (IMT).

BACKGROUND: Common carotid artery intima-media thickness has been associated with the incidence of cardiovascular disease.

METHOD: Noninvasive measurements of IMT were made with high-resolution ultrasonography in 5,640 subjects 65 years of age or older participating in the Cardiovascular Health Study. New coronary and/or cerebrovascular events served as outcome variables over a median 10.2-year follow-up. To characterize different carotid structural geometric patterns (CGP), vascular mass (VM) was combined with the wall-to-lumen ratio (W/L). Normal values for W/L and VM were defined as age-adjusted, gender-specific 75th percentiles of the 1,899 normotensive subjects free of CVD at baseline. Four CGPs were defined: CGP1 = normal W/L ratio and VM; CGP2 = arterial remodeling (i.e., increased W/L ratio with normal VM); CGP3 = arterial hypertrophy (i.e., increased W/L ratio with increased VM); and CGP4 = arterial hypertrophy with dilation (i.e., normal W/L ratio and increased VM).

RESULTS: Coronary or cerebrovascular events (adjusted for age, gender, traditional risk factors, and IMT) were associated with CGP in subjects free of CVD at baseline. Specifically, the hazard ratio (Cox proportional-hazards analyses) for CGP3 (arterial hypertrophy) was 1.25 (95% confidence interval [CI] 1.03 to 1.53), and for CGP4 (arterial hypertrophy with dilation) was 1.43 (95% CI 1.16 to 1.75) compared with CGP1 (normal).

CONCLUSIONS: Arterial hypertrophy defined by variant CGP patterns is associated with the development of new CVD, independent of age, traditional risk factors, and CCA IMT.

10aAged10aCardiovascular Diseases10aCarotid Arteries10aFemale10aHumans10aHypertrophy10aIncidence10aMale10aPredictive Value of Tests10aPrevalence10aProspective Studies10aUltrasonography1 aScuteri, Angelo1 aManolio, Teri, A1 aMarino, Emily, K1 aArnold, Alice, M1 aLakatta, Edward, G uhttps://chs-nhlbi.org/node/764