03248nas a2200385   4500008004100000022001400041245012500055210006900180260001700249300001000266490000700276520210200283653000902385653002102394653002802415653001902443653001102462653003102473653002502504653000902529653002602538653001502564653002402579653002902603653002002632653001802652100002402670700002502694700002302719700002302742700002202765700001902787700002102806856003502827       2004                        eng d  a1538-574400aAssociations between renovascular disease and prevalent cardiovascular disease in the elderly: a population-based study.0 aAssociations between renovascular disease and prevalent cardiova  c2004 Jan-Feb  a25-350 v383 a<p>Atherosclerotic renovascular disease (RVD) is a suspected contributor to the morbidity and mortality of cardiovascular disease (CVD) through its potential effects on blood pressure and excretory renal function as well as through its associations with other forms of CVD. However, population-based data regarding the associations between the presence of RVD and prevalent CVD are lacking. The Cardiovascular Health Study (CHS) is a prospective, multicenter cohort study of CVD among elderly Americans. As part of an ancillary study, participants in the Forsyth County, North Carolina, cohort of the CHS were invited to undergo renal duplex sonography (RDS) to establish the presence or absence of RVD (defined as any focal peak systolic velocity >/= 1.8 m/second or the absence of a Doppler-shifted signal from an imaged artery). Demographic, risk factor, and prevalent CVD data were obtained from the CHS coordinating center and matched with ancillary study participants. Eight hundred thirty-four CHS participants (including 525 women [63%], 309 men [37%], 194 African-Americans [23%], and 635 Caucasians [76%]) with a mean age of 77.2 +/-4.9 years underwent RDS examination. RVD was present in 57 participants (6.8%). Overall, clinical and/or subclinical manifestations of CVD were present in 603 participants (72.3%) at the time of RDS. Participants with RVD demonstrated a significantly greater prevalence of angina (p = 0.002), previous myocardial infarction (p < 0.001), >/= 25% diameter-reducing internal carotid artery stenosis (p = 0.010), increased carotid intimal medial thickness (p = 0.003), and major electrocardiographic abnormalities (p = 0.013). Following adjustment for demographics and cardiovascular risk factors, the presence of RVD demonstrated a significant and independent association with prevalent coronary artery disease but not with prevalent cerebrovascular or lower extremity vascular disease. These results suggest important population-based associations between RVD and both clinical and subclinical manifestations of CVD, especially coronary artery disease.</p>10aAged10aArteriosclerosis10aCardiovascular Diseases10aCohort Studies10aHumans10aHypertension, Renovascular10aLongitudinal Studies10aMale10aMultivariate Analysis10aPrevalence10aProspective Studies10aRenal Artery Obstruction10aUltrasonography10aUnited States1 aEdwards, Matthew, S1 aHansen, Kimberley, J1 aCraven, Timothy, E1 aBleyer, Anthony, J1 aBurke, Gregory, L1 aLevy, Pavel, J1 aDean, Richard, H  uhttps://chs-nhlbi.org/node/765