02554nas a2200385 4500008004100000022001400041245012100055210006900176260001700245300001000262490000700272520146800279653000901747653003001756653002801786653002001814653001501834653001501849653001401864653001101878653001501889653002501904653001101929653001401940653000901954653001501963653002401978653001702002100002402019700002002043700002902063700002102092700002002113856003502133 2004 eng d a1076-746000aChronic renal insufficiency and cardiovascular events in the elderly: findings from the Cardiovascular Health Study.0 aChronic renal insufficiency and cardiovascular events in the eld c2004 Mar-Apr a81-900 v133 a
In the Cardiovascular Health Study, the authors sought to evaluate the impact of chronic renal insufficiency (CRI) on cardiovascular risk status and outcomes in a representative sample of community-dwelling elderly adults. Defined as a serum creatinine level > or =1.3 mg/dL in women and > or =1.5 mg/dL in men, CRI was present in 647 (11%) of 5808 participants. At baseline, the prevalence of clinical or subclinical cardiovascular disease was 64% in participants with CRI and 43% in those without CRI (odds ratio, 2.34; 95% confidence interval, 1.96-2.80). The incidence of cardiovascular disease events during follow-up was 3% per year in participants with creatinine levels <1.10 mg/dL and increased steadily to reach 7% per year in those with creatinine > or =1.70 mg/dL. Among the possible mediators for the association between CRI and cardiovascular morbidity are inflammatory (C-reactive protein, fibrinogen, and interleukin-6) and hemostatic (factor VII, factor VIII, plasmin-antiplasmin product, and D-dimer) biomarkers, all of which were significantly elevated in Cardiovascular Health Study participants with CRI. Future studies should evaluate the contribution of novel and traditional cardiovascular risk factors to the cardiovascular risk of elderly persons with CRI. The identification of CRI in the elderly and the use of cardiovascular prevention therapies represent a major opportunity to reduce their burden of cardiovascular morbidity.
10aAged10aBlood Coagulation Factors10aCardiovascular Diseases10aChronic Disease10aCreatinine10aCystatin C10aCystatins10aFemale10aFibrinogen10aGeriatric Assessment10aHumans10aIncidence10aMale10aPrevalence10aRenal Insufficiency10aRisk Factors1 aShlipak, Michael, G1 aFried, Linda, F1 aStehman-Breen, Catherine1 aSiscovick, David1 aNewman, Anne, B uhttps://chs-nhlbi.org/node/773